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{{Infobox_gene}}
'''Frizzled-9''' is a [[protein]] that in humans is encoded by the ''FZD9'' [[gene]].<ref name="pmid9147651">{{cite journal | vauthors = Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U | title = A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23 | journal = Human Molecular Genetics | volume = 6 | issue = 3 | pages = 465–72 | date = Mar 1997 | pmid = 9147651 | pmc =  | doi = 10.1093/hmg/6.3.465 }}</ref><ref name="pmid10198163">{{cite journal | vauthors = Wang YK, Spörle R, Paperna T, Schughart K, Francke U | title = Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome | journal = Genomics | volume = 57 | issue = 2 | pages = 235–48 | date = Apr 1999 | pmid = 10198163 | pmc =  | doi = 10.1006/geno.1999.5773 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326| accessdate = }}</ref> FZD9 has also been designated as '''CD349''' ([[cluster of differentiation]] 349).


== Function ==


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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype.  FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.<ref name="entrez" />
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Frizzled homolog 9 (Drosophila)
| HGNCid = 4047
| Symbol = FZD9
| AltSymbols =; FZD3
| OMIM = 601766
| ECnumber = 
| Homologene = 2619
| MGIid = 1313278
| GeneAtlas_image1 = PBB_GE_FZD9_207639_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0043350 |text = neuroblast proliferation (sensu Vertebrata)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8326
    | Hs_Ensembl = ENSG00000188763
    | Hs_RefseqProtein = NP_003499
    | Hs_RefseqmRNA = NM_003508
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 72486045
    | Hs_GenLoc_end = 72488386
    | Hs_Uniprot = O00144
    | Mm_EntrezGene = 14371
    | Mm_Ensembl = ENSMUSG00000049551
    | Mm_RefseqmRNA = XM_284144
    | Mm_RefseqProtein = XP_284144
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 135533878
    | Mm_GenLoc_end = 135535656
    | Mm_Uniprot = Q9R216
  }}
}}
'''Frizzled homolog 9 (Drosophila)''', also known as '''FZD9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326| accessdate = }}</ref> FZD9 has also been designated as '''CD349''' ([[cluster of differentiation]] 349).
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype.  FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.<ref name="entrez">{{cite web | title = Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8326| accessdate = }}</ref>
}}
 
==See also==
* [[Frizzled]]
* [[Frizzled]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Datta DV | title = Viral hepatitis (Chandigarh study) | journal = The Journal of the Association of Physicians of India | volume = 25 | issue = 5 | pages = 325–30 | date = May 1977 | pmid = 914765 | doi =  }}
| citations =
* {{cite journal | vauthors = Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 13 | pages = 6770–5 | date = Jun 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 }}
*{{cite journal | author=Datta DV |title=Viral hepatitis (Chandigarh study). |journal=The Journal of the Association of Physicians of India |volume=25 |issue= 5 |pages= 325-30 |year= 1977 |pmid= 914765 |doi=  }}
* {{cite journal | vauthors = Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 17 | pages = 10164–9 | date = Aug 1998 | pmid = 9707618 | pmc = 21479 | doi = 10.1073/pnas.95.17.10164 }}
*{{cite journal | author=Wang YK, Samos CH, Peoples R, ''et al.'' |title=A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. |journal=Hum. Mol. Genet. |volume=6 |issue= 3 |pages= 465-72 |year= 1997 |pmid= 9147651 |doi=  }}
* {{cite journal | vauthors = Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ | title = Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37479–86 | date = Oct 2002 | pmid = 12138115 | doi = 10.1074/jbc.M205658200 }}
*{{cite journal  | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi= }}
* {{cite journal | vauthors = Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genetics | volume = 25 | issue = 2 | pages = 81–90 | date = Jun 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
*{{cite journal | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi=  }}
* {{cite journal | vauthors = Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE | title = Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 20 | pages = 19625–34 | date = May 2005 | pmid = 15705594 | doi = 10.1074/jbc.M409392200 }}
*{{cite journal  | author=Wang YK, Spörle R, Paperna T, ''et al.'' |title=Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. |journal=Genomics |volume=57 |issue= 2 |pages= 235-48 |year= 1999 |pmid= 10198163 |doi= 10.1006/geno.1999.5773 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ |title=Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37479-86 |year= 2002 |pmid= 12138115 |doi= 10.1074/jbc.M205658200 }}
* {{cite journal | vauthors = Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA | title = Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 281 | issue = 37 | pages = 26943–50 | date = Sep 2006 | pmid = 16835228 | doi = 10.1074/jbc.M604145200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal | author=Winn RA, Marek L, Han SY, ''et al.'' |title=Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19625-34 |year= 2005 |pmid= 15705594 |doi= 10.1074/jbc.M409392200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Winn RA, Van Scoyk M, Hammond M, ''et al.'' |title=Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26943-50 |year= 2006 |pmid= 16835228 |doi= 10.1074/jbc.M604145200 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3067 | title = Frizzled Receptors: FZD<sub>9</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{MeshName|FZD9+protein,+human}}
* {{MeshName|FZD9+protein,+human}}


{{transmembranereceptor-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}


[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]
 
{{WH}}
{{WS}}

Latest revision as of 18:00, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-9 is a protein that in humans is encoded by the FZD9 gene.[1][2][3] FZD9 has also been designated as CD349 (cluster of differentiation 349).

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[3]

See also

References

  1. ↑ Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
  2. ↑ Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
  3. ↑ 3.0 3.1 "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

Further reading

  • Datta DV (May 1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India. 25 (5): 325–30. PMID 914765.
  • Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
  • Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
  • Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (Oct 2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". The Journal of Biological Chemistry. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.
  • Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
  • Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE (May 2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". The Journal of Biological Chemistry. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA (Sep 2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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