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RefSeq (mRNA)



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Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).


The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]


LAIR1 has been shown to interact with PTPN11[1][3] and PTPN6.[1][3][4][5][6]


  1. 1.0 1.1 1.2 Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
  2. 2.0 2.1 "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".
  3. 3.0 3.1 Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
  4. Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
  5. Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
  6. Xu Mj, Zhao R, Zhao ZJ (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.

Further reading

  • Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045.
  • Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology 244 and Immunology. 244: 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657.
  • Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents. 17 (4): 330–3. PMID 15065762.
  • Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876.
  • Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813.
  • van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". Eur. J. Immunol. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
  • Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
  • Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
  • Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
  • Aoukaty A, Lee IF, Wu J, Tan R (2003). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266.
  • Verbrugge A, de Ruiter T, Clevers H, Meyaard L (2003). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.
  • De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, Grutzmeier S, Sönnerborg A, Chiodi F (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood. 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.