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Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
External IDs Template:OMIM5 HomoloGene48243
RNA expression pattern
File:PBB GE TNFRSF10D 210654 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain, also known as TNFRSF10D, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[1]


  1. 1.0 1.1 "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Further reading

  • Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/ PMID 15538968.
  • Marsters SA, Sheridan JP, Pitti RM; et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr. Biol. 7 (12): 1003–6. PMID 9382840.
  • Degli-Esposti MA, Dougall WC, Smolak PJ; et al. (1998). "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain". Immunity. 7 (6): 813–20. PMID 9430226.
  • Pan G, Ni J, Yu G; et al. (1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling". FEBS Lett. 424 (1–2): 41–5. PMID 9537512.
  • Phillips TA, Ni J, Pan G; et al. (1999). "TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege". J. Immunol. 162 (10): 6053–9. PMID 10229846.
  • Zhang XD, Franco AV, Nguyen T; et al. (2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells". J. Immunol. 164 (8): 3961–70. PMID 10754286.
  • Daigle I, Simon HU (2001). "Alternative functions for TRAIL receptors in eosinophils and neutrophils". Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology. 131 (17–18): 231–7. doi:2001/17/smw-09707 Check |doi= value (help). PMID 11420819.
  • Dörr J, Bechmann I, Waiczies S; et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. PMID 11844843.
  • Sun SY, Yue P, Chen X; et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells". Cancer Res. 62 (8): 2430–6. PMID 11956107.
  • Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain". Brain. 125 (Pt 11): 2469–80. PMID 12390973.
  • Robertson NM, Zangrilli JG, Steplewski A; et al. (2003). "Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival". J. Immunol. 169 (10): 5986–96. PMID 12421985.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ou D, Metzger DL, Wang X; et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678–88. doi:10.1007/s00125-002-0926-2. PMID 12488957.
  • Hasel C, Dürr S, Rau B; et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas". Lab. Invest. 83 (6): 825–36. PMID 12808117.
  • Kotelkin A, Prikhod'ko EA, Cohen JI; et al. (2003). "Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand". J. Virol. 77 (17): 9156–72. PMID 12915532.
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
  • Shivapurkar N, Toyooka S, Toyooka KO; et al. (2004). "Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types". Int. J. Cancer. 109 (5): 786–92. doi:10.1002/ijc.20041. PMID 14999791.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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