Interleukin 11 receptor alpha subunit

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External IDs	GeneCards: [1]
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Species	Human	Mouse
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Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

Further reading

• Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): 2534–40. PMID 7670098.
• Chérel M, Sorel M, Apiou F, et al. (1996). "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics. 32 (1): 49–53. doi:10.1006/geno.1996.0075. PMID 8786120.
• Van Leuven F, Stas L, Hilliker C, et al. (1996). "Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13". Genomics. 31 (1): 65–70. doi:10.1006/geno.1996.0010. PMID 8808281.
• Magrangeas F, Pitiot G, Dubois S, et al. (1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution". J. Biol. Chem. 273 (26): 16005–10. doi:10.1074/jbc.273.26.16005. PMID 9632650.
• Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11". J. Biol. Chem. 274 (9): 5755–61. doi:10.1074/jbc.274.9.5755. PMID 10026196.
• Tacken I, Dahmen H, Boisteau O, et al. (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem. 265 (2): 645–55. doi:10.1046/j.1432-1327.1999.00755.x. PMID 10504396.
• Campbell CL, Jiang Z, Savarese DM, Savarese TM (2001). "Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma". Am. J. Pathol. 158 (1): 25–32. doi:10.1016/S0002-9440(10)63940-5. PMC 1850253. PMID 11141475.
• Cork BA, Tuckerman EM, Li TC, Laird SM (2003). "Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro". Mol. Hum. Reprod. 8 (9): 841–8. doi:10.1093/molehr/8.9.841. PMID 12200462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Karpovich N, Chobotova K, Carver J, et al. (2003). "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75–80. doi:10.1093/molehr/gag012. PMC 1626582. PMID 12569176.
• Kiessling S, Muller-Newen G, Leeb SN, et al. (2004). "Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells". J. Biol. Chem. 279 (11): 10304–15. doi:10.1074/jbc.M312757200. PMID 14701802.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zurita AJ, Troncoso P, Cardó-Vila M, et al. (2004). "Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer". Cancer Res. 64 (2): 435–9. doi:10.1158/0008-5472.CAN-03-2675. PMID 14744752.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tsimanis A, Shtalrid M, Shvidel L, et al. (2005). "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma. 45 (11): 2315–9. doi:10.1080/10428190412331283161. PMID 15512823.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Karube K, Ohshima K, Suzumiya J, et al. (2006). "Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha". Ann. Oncol. 17 (1): 110–6. doi:10.1093/annonc/mdj064. PMID 16291580.
• Hanavadi S, Martin TA, Watkins G, et al. (2006). "Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer". Ann. Surg. Oncol. 13 (6): 802–8. doi:10.1245/ASO.2006.05.028. PMID 16614887.
• Yoshizaki A, Nakayama T, Yamazumi K, et al. (2006). "Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells". Int. J. Oncol. 29 (4): 869–76. doi:10.3892/ijo.29.4.869. PMID 16964382.
• Nakayama T, Yoshizaki A, Izumida S, et al. (2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells". Int. J. Oncol. 30 (4): 825–33. doi:10.3892/ijo.30.4.825. PMID 17332920.