Interleukin-3 receptor

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interleukin 3 receptor, alpha
Alt. symbolsCD123
Other data
LocusChr. X p22.3
interleukin 3 receptor, Y-Chromosomal
Alt. symbolsIL3RY, IL3RAY
Other data
LocusChr. Y p11.3

The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

Cell types and function

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. It can be found on basophils and pDCs as well as some cDCs among peripheral blood mononuclear cells.

CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.[1]

Possible drug target

An experimental antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.[1]


External links