Decay accelerating factor
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|CD55 molecule, decay accelerating factor for complement (Cromer blood group)|
|Locus||Chr. 1 q32|
Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.
DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.
- Decay-Accelerating+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
- Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH