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Tumor necrosis factor (ligand) superfamily, member 14
Symbols TNFSF14 ; TR2; CD258; HVEML; LIGHT; LTg
External IDs Template:OMIM5 Template:MGI HomoloGene2822
RNA expression pattern
File:PBB GE TNFSF14 207907 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor (ligand) superfamily, member 14, also known as TNFSF14, is a human gene.[1] TNFSF14 has also been designated as CD258 (cluster of differentiation 258).

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.[1]


  1. 1.0 1.1 "Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14".

Further reading

  • Yang D, Zhai Y, Zhang M (2003). "LIGHT, a new member of the TNF superfamily". J. Biol. Regul. Homeost. Agents. 16 (3): 206–10. PMID 12456019.
  • Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. PMID 12836198.
  • Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell". Current HIV/AIDS reports. 1 (1): 47–53. PMID 16091223.
  • Mauri DN, Ebner R, Montgomery RI; et al. (1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21–30. PMID 9462508.
  • Marsters SA, Sheridan JP, Pitti RM; et al. (1998). "Identification of a ligand for the death-domain-containing receptor Apo3". Curr. Biol. 8 (9): 525–8. PMID 9560343.
  • Zhai Y, Guo R, Hsu TL; et al. (1998). "LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer". J. Clin. Invest. 102 (6): 1142–51. PMID 9739048.
  • Harrop JA, McDonnell PC, Brigham-Burke M; et al. (1998). "Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth". J. Biol. Chem. 273 (42): 27548–56. PMID 9765287.
  • Yu KY, Kwon B, Ni J; et al. (1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J. Biol. Chem. 274 (20): 13733–6. PMID 10318773.
  • Rooney IA, Butrovich KD, Glass AA; et al. (2000). "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells". J. Biol. Chem. 275 (19): 14307–15. PMID 10799510.
  • Lama J, Ware CF (2000). "Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells". J. Virol. 74 (20): 9396–402. PMID 11000208.
  • Morel Y, Schiano de Colella JM, Harrop J; et al. (2000). "Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor". J. Immunol. 165 (8): 4397–404. PMID 11035077.
  • Zhang J, Salcedo TW, Wan X; et al. (2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. 107 (11): 1459–68. PMID 11390428.
  • Granger SW, Butrovich KD, Houshmand P; et al. (2001). "Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis". J. Immunol. 167 (9): 5122–8. PMID 11673523.
  • Shaikh RB, Santee S, Granger SW; et al. (2002). "Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction". J. Immunol. 167 (11): 6330–7. PMID 11714797.
  • Bobik A, Kalinina N (2002). "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis". Arterioscler. Thromb. Vasc. Biol. 21 (12): 1873–5. PMID 11742858.
  • Wang J, Lo JC, Foster A; et al. (2002). "The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT". J. Clin. Invest. 108 (12): 1771–80. PMID 11748260.
  • Hsu TL, Chang YC, Chen SJ; et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. PMID 11994433.
  • Castellano R, Van Lint C, Peri V; et al. (2003). "Mechanisms regulating expression of the tumor necrosis factor-related light gene. Role of calcium-signaling pathway in the transcriptional control". J. Biol. Chem. 277 (45): 42841–51. doi:10.1074/jbc.M207689200. PMID 12215452.
  • Matsui H, Hikichi Y, Tsuji I; et al. (2003). "LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis". J. Biol. Chem. 277 (51): 50054–61. doi:10.1074/jbc.M206562200. PMID 12393901.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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