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Tumor necrosis factor receptor superfamily, member 10b
File:PBB Protein TNFRSF10B image.jpg
PDB rendering based on 1d0g.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
External IDs Template:OMIM5 HomoloGene88698
RNA expression pattern
File:PBB GE TNFRSF10B 209295 at tn.png
File:PBB GE TNFRSF10B 209294 x at tn.png
File:PBB GE TNFRSF10B 210405 x at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 10b, also known as TNFRSF10B, is a human gene.

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]

See also


  1. "Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b".

Further reading

  • Abe K, Kurakin A, Mohseni-Maybodi M; et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand". Ann. N. Y. Acad. Sci. 926: 52–63. PMID 11193041.
  • Cha SS, Song YL, Oh BH (2004). "Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex". Vitam. Horm. 67: 1–17. doi:10.1016/S0083-6729(04)67001-4. PMID 15110168.
  • Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/ PMID 15538968.
  • Pan G, Ni J, Wei YF; et al. (1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL". Science. 277 (5327): 815–8. PMID 9242610.
  • Sheridan JP, Marsters SA, Pitti RM; et al. (1997). "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors". Science. 277 (5327): 818–21. PMID 9242611.
  • Screaton GR, Mongkolsapaya J, Xu XN; et al. (1998). "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL". Curr. Biol. 7 (9): 693–6. PMID 9285725.
  • Walczak H, Degli-Esposti MA, Johnson RS; et al. (1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMID 9311998.
  • MacFarlane M, Ahmad M, Srinivasula SM; et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. PMID 9325248.
  • Wu GS, Burns TF, McDonald ER; et al. (1997). "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene". Nat. Genet. 17 (2): 141–3. doi:10.1038/ng1097-141. PMID 9326928.
  • Schneider P, Bodmer JL, Thome M; et al. (1997). "Characterization of two receptors for TRAIL". FEBS Lett. 416 (3): 329–34. PMID 9373179.
  • Marsters SA, Sheridan JP, Pitti RM; et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr. Biol. 7 (12): 1003–6. PMID 9382840.
  • Chaudhary PM, Eby M, Jasmin A; et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821–30. PMID 9430227.
  • Schneider P, Thome M, Burns K; et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB". Immunity. 7 (6): 831–6. PMID 9430228.
  • Pai SI, Wu GS, Ozören N; et al. (1998). "Rare loss-of-function mutation of a death receptor gene in head and neck cancer". Cancer Res. 58 (16): 3513–8. PMID 9721851.
  • Arai T, Akiyama Y, Okabe S; et al. (1999). "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas". Cancer Lett. 133 (2): 197–204. PMID 10072170.
  • Mongkolsapaya J, Grimes JM, Chen N; et al. (2002). "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation". Nat. Struct. Biol. 6 (11): 1048–53. doi:10.1038/14935. PMID 10542098.
  • Hymowitz SG, Christinger HW, Fuh G; et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5". Mol. Cell. 4 (4): 563–71. PMID 10549288.
  • Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts". J. Biol. Chem. 275 (33): 25065–8. doi:10.1074/jbc.C000284200. PMID 10862756.
  • Trauzold A, Wermann H, Arlt A; et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells". Oncogene. 20 (31): 4258–69. doi:10.1038/sj.onc.1204559. PMID 11464292.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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