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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[1][2]


The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[2]

See also


  1. Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID 11707068.
  2. 2.0 2.1 "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2".

Further reading

  • Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology. 143 (3): 737–43. doi:10.1210/en.143.3.737. PMID 11861490.
  • Millar R, Conklin D, Lofton-Day C, et al. (1999). "A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript". J. Endocrinol. 162 (1): 117–26. doi:10.1677/joe.0.1620117. PMID 10396028.
  • Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates". Biochem. Biophys. Res. Commun. 282 (4): 1012–8. doi:10.1006/bbrc.2001.4678. PMID 11352653.
  • van Biljon W, Wykes S, Scherer S, et al. (2003). "Type II gonadotropin-releasing hormone receptor transcripts in human sperm". Biol. Reprod. 67 (6): 1741–9. doi:10.1095/biolreprod.101.002808. PMID 12444048.
  • Morgan K, Conklin D, Pawson AJ, et al. (2003). "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12". Endocrinology. 144 (2): 423–36. doi:10.1210/en.2002-220622. PMID 12538601.
  • Pawson AJ, Maudsley S, Morgan K, et al. (2005). "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology. 146 (6): 2639–49. doi:10.1210/en.2005-0133. PMID 15761034.
  • Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. doi:10.1530/eje.1.02005. PMID 16189182.
  • Ikemoto T, Park MK (2006). "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics. 87 (4): 459–62. doi:10.1016/j.ygeno.2005.11.005. PMID 16406723.
  • Parker JD, Malik M, Catherino WH (2007). "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. doi:10.1016/j.fertnstert.2006.11.098. PMID 17296196.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.