Alpha-1B adrenergic receptor

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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The alpha-1B adrenergic receptor1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[1]

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.[1]

Ligands

Antagonists

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.[3] A role in regulation of dopaminergic neurotransmission has also been suggested.[4][5]

See also

References

  1. 1.0 1.1 "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. PMID 11923452.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

Further reading

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  • Ramarao CS, Denker JM, Perez DM, et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor". J. Biol. Chem. 267 (30): 21936–45. PMID 1328250.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity" (PDF). Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Lomasney JW, Cotecchia S, Lorenz W, et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. PMID 1706716.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Schwinn DA, Johnston GI, Page SO, et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Weinberg DH, Trivedi P, Tan CP, et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Forray C, Bard JA, Wetzel JM, et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Diviani D, Lattion AL, Larbi N, et al. (1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. doi:10.1074/jbc.271.9.5049. PMID 8617782.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Diviani D, Lattion AL, Cotecchia S (1997). "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. doi:10.1074/jbc.272.45.28712. PMID 9353340.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Sasaguri T, Teruya H, Ishida A, et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. doi:10.1006/bbrc.1999.2066. PMID 10652206.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Minneman KP, Lee D, Zhong H, et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Shibata K, Katsuma S, Koshimizu T, et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Diviani D, Lattion AL, Abuin L, et al. (2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. doi:10.1124/mol.63.5.1104. PMID 12695539.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Hague C, Uberti MA, Chen Z, et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Kang SK, Yi KS, Kwon NS, et al. (2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200. PMID 15220331.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gonzalez-Cabrera PJ, Shi T, Yun J, et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology. 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Zhang T, Xu Q, Chen FR, et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>