Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene .[1] [2] [3] In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o -coupled .[4]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][3]
See also
References
↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 .
↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics . 85 (3): 372–85. doi :10.1016/j.ygeno.2004.11.010 . PMID 15718104 .
↑ 3.0 3.1 "Entrez Gene: TAAR8 trace amine associated receptor 8" .
↑ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H (2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile" . Int J Mol Sci . 15 (11): 20638–55. doi :10.3390/ijms151120638 . PMC 4264187 . PMID 25391046 .
Further reading
Borowsky B, Adham N, Jones KA, et al. (2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors" . Proc. Natl. Acad. Sci. U.S.A . 98 (16): 8966–71. doi :10.1073/pnas.151105198 . PMC 55357 . PMID 11459929 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature . 425 (6960): 805–11. doi :10.1038/nature02055 . PMID 14574404 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
TAAR1
TAAR2
Agonists‡
Neutral antagonists
TAAR5
Agonists‡ Neutral antagonists Inverse agonists‡
‡ References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see TAAR for references.
See also: Receptor/signaling modulators