GPR37

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.

Interactions

GPR37 has been shown to interact with HSPA1A and Parkin (ligase). GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.

Further reading

• Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochem. Biophys. Res. Commun. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
• Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system". Brain Res. Mol. Brain Res. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.
• Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
• Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
• Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila". Neuron. 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.
• Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
• Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". J. Neurochem. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
• Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y (2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin" (PDF). J. Neurochem. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.