Neurotensin receptor 2

Jump to navigation Jump to search
External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
PubMed searchn/an/a
View/Edit Human

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]


The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]

See also


  1. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296.
  2. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
  3. 3.0 3.1 "Entrez Gene: NTSR2 neurotensin receptor 2".

Further reading

  • Vincent JP, Mazella J, Kitabgi P (Jul 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
  • Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (Sep 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience. 16 (18): 5613–20. PMID 8795617.
  • Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A (Sep 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
  • Martin S, Vincent JP, Mazella J (Jan 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science. 115 (Pt 1): 165–73. PMID 11801734.
  • Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L (Jun 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science. 43 (6): 1765–71. PMID 12036977.
  • Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
  • Somaï S, Gompel A, Rostène W, Forgez P (Jul 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
  • Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (Dec 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links