Corticotropin-like intermediate peptide

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Other data
LocusChr. 2 p23
Template:Chembox E number
Corticotropin-like intermediate peptide
IUPAC name
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Molar mass 2465.668 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Its physiological role has been investigated in various tissues,[4][5] specifically in the central nervous system.[6][7][8][9][10]


  1. Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883.
  2. Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78. ISBN 978-0-8493-8852-1. Retrieved 25 November 2011.
  3. Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. p. 12. ISBN 978-0-12-521441-4. Retrieved 25 November 2011.
  4. Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
  5. Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.
  6. Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136. ISBN 978-0-8493-4822-8. Retrieved 25 November 2011.
  7. Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.
  8. Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.
  9. Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.
  10. Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.

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