Neuropeptide Y receptor Y1

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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
PubMed searchn/an/a
View/Edit Human

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[1][2]

Selective ligands



  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures

  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[3]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[3]

See also


  1. Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. "Entrez Gene: NPY1R neuropeptide Y receptor Y1".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. 3.0 3.1 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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  • Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry. 267 (16): 10935–8. PMID 1317848.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Körner M, Waser B, Reubi JC (December 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

  • "Neuropeptide Y Receptors: Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>