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↑Chng, S. C., Ho, L., Tian, J., & Reversade, B. (2013). ELABELA: a hormone essential for heart development signals via the apelin receptor. Developmental Cell, 27(6), 672–680. doi:10.1016/j.devcel.2013.11.002
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Further reading
Hinohara K, Nakajima T, Sasaoka T, et al. (2009). "Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations". J. Hum. Genet. 54 (9): HASH(0x28fffa0). doi:10.1038/jhg.2009.78. PMID19680269.
Hata J, Matsuda K, Ninomiya T, et al. (2007). "Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction". Hum. Mol. Genet. 16 (6): 630–9. doi:10.1093/hmg/ddm005. PMID17309882.
Kälin RE, Kretz MP, Meyer AM, et al. (2007). "Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis". Dev. Biol. 305 (2): 599–614. doi:10.1016/j.ydbio.2007.03.004. PMID17412318.
Zhou N, Zhang X, Fan X, et al. (2003). "The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity". Virology. 317 (1): 84–94. doi:10.1016/j.virol.2003.08.026. PMID14675627.
Otsuki T, Ota T, Nishikawa T, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
O'Carroll AM, Don AL, Lolait SJ (2003). "APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids". J. Neuroendocrinol. 15 (11): 1095–101. doi:10.1046/j.1365-2826.2003.01102.x. PMID14622440.
Sarzani R, Forleo C, Pietrucci F, et al. (2007). "The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy". J. Card. Fail. 13 (7): 521–9. doi:10.1016/j.cardfail.2007.04.002. PMID17826642.
Langelaan DN, Bebbington EM, Reddy T, Rainey JK (2009). "Structural insight into G-protein coupled receptor binding by apelin". Biochemistry. 48 (3): 537–48. doi:10.1021/bi801864b. PMID19123778.
Zhou N, Fan X, Mukhtar M, et al. (2003). "Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ". Virology. 307 (1): 22–36. doi:10.1016/S0042-6822(02)00021-1. PMID12667811.
Li WW, Niu WQ, Zhang Y, et al. (2009). "Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese". J. Hypertens. 27 (6): 1194–201. doi:10.1097/HJH.0b013e32832a3eb1. PMID19307984.
Lee DK, Lança AJ, Cheng R, et al. (2004). "Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors". J. Biol. Chem. 279 (9): 7901–8. doi:10.1074/jbc.M306377200. PMID14645236.
Choe H, Martin KA, Farzan M, et al. (1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Semin. Immunol. 10 (3): 249–57. doi:10.1006/smim.1998.0127. PMID9653051.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Kleinz MJ, Skepper JN, Davenport AP (2005). "Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells". Regul. Pept. 126 (3): 233–40. doi:10.1016/j.regpep.2004.10.019. PMID15664671.
Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID18240029.
Cobellis L, De Falco M, Mastrogiacomo A, et al. (2007). "Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas". Histol. Histopathol. 22 (1): 1–8. PMID17128405.
Kubo M (2008). "[Genetic risk factors of ischemic stroke identified by a genome-wide association study]". Brain and nerve = Shinkei kenkyÅ« no shinpo. 60 (11): 1339–46. PMID19069168.
Bai B, Tang J, Liu H, et al. (2008). "Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway". Acta Biochim. Biophys. Sin. (Shanghai). 40 (4): 311–8. doi:10.1111/j.1745-7270.2008.00403.x. PMID18401529.
Ishida J, Hashimoto T, Hashimoto Y, et al. (2004). "Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo". J. Biol. Chem. 279 (25): 26274–9. doi:10.1074/jbc.M404149200. PMID15087458.
External links
"Apelin Receptor: APJ". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.