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{{Infobox_gene}}
'''Kinase insert domain receptor''' ('''KDR''', a type III receptor tyrosine kinase) also known as '''vascular endothelial growth factor receptor 2''' ('''VEGFR-2''') is a [[VEGF receptor]]. ''KDR'' is the human [[gene]] encoding it. KDR has also been designated as '''CD309''' ([[cluster of differentiation]] 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).


The Q472H germline ''KDR'' genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in [[Non-small-cell lung carcinoma|NSCLC]].<ref>{{cite journal | vauthors = Glubb DM, Cerri E, Giese A, Zhang W, Mirza O, Thompson EE, Chen P, Das S, Jassem J, Rzyman W, Lingen MW, Salgia R, Hirsch FR, Dziadziuszko R, Ballmer-Hofer K, Innocenti F | title = Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer | journal = Clinical Cancer Research | volume = 17 | issue = 16 | pages = 5257–67 | date = August 2011 | pmid = 21712447 | pmc = 3156871 | doi = 10.1158/1078-0432.CCR-11-0379 | url = http://clincancerres.aacrjournals.org/content/17/16/5257 }}</ref>




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== Interactions ==
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Kinase insert domain receptor has been shown to [[Protein-protein interaction|interact]] with [[SHC2]],<ref name=pmid10749680>{{cite journal | vauthors = Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA | title = The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells | journal = The Biochemical Journal | volume = 347 | issue = Pt 2 | pages = 501–9 | date = April 2000 | pmid = 10749680 | pmc = 1220983 | doi = 10.1042/0264-6021:3470501 }}</ref> [[Annexin A5]]<ref name=pmid10329451>{{cite journal | vauthors = Wen Y, Edelman JL, Kang T, Sachs G | title = Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1 | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 3 | pages = 713–21 | date = May 1999 | pmid = 10329451 | doi = 10.1006/bbrc.1999.0678 }}</ref> and [[SHC1]].<ref name=pmid11950700>{{cite journal | vauthors = Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M, Lanfrancone L, Dejana E | title = Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 22 | issue = 4 | pages = 617–22 | date = April 2002 | pmid = 11950700 | doi = 10.1161/01.ATV.0000012268.84961.AD }}</ref><ref name=pmid10319320>{{cite journal | vauthors = D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI | title = 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells | journal = Molecular Endocrinology | volume = 13 | issue = 5 | pages = 692–704 | date = May 1999 | pmid = 10319320 | doi = 10.1210/mend.13.5.0280 }}</ref>
{{GNF_Protein_box
| image =
| image_source =


| Name = Kinase insert domain receptor (a type III receptor tyrosine kinase)
== See also ==
| HGNCid = 6307
* [[Cluster of differentiation]]
| Symbol = KDR
* [[VEGF receptors]]
| AltSymbols =; CD309; FLK1; VEGFR; VEGFR2
| OMIM = 191306
| ECnumber = 
| Homologene = 55639
| MGIid = 96683
| GeneAtlas_image1 = PBB_GE_KDR_203934_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005021 |text = vascular endothelial growth factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}} {{GNF_GO|id=GO:0045446 |text = endothelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3791
    | Hs_Ensembl = ENSG00000128052
    | Hs_RefseqProtein = NP_002244
    | Hs_RefseqmRNA = NM_002253
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 55639401
    | Hs_GenLoc_end = 55686519
    | Hs_Uniprot = P35968
    | Mm_EntrezGene = 16542
    | Mm_Ensembl = ENSMUSG00000062960
    | Mm_RefseqmRNA = XM_984991
    | Mm_RefseqProtein = XP_990085
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 76214954
    | Mm_GenLoc_end = 76260125
    | Mm_Uniprot = Q3UQZ6
  }}
}}
'''Kinase insert domain receptor (a type III receptor tyrosine kinase)''', also known as '''KDR''', is a human [[gene]].
 
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| summary_text =
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==See also==
== References ==
* [[VEGF receptors]]
{{Reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Holmes K, Roberts OL, Thomas AM, Cross MJ | title = Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition | journal = Cellular Signalling | volume = 19 | issue = 10 | pages = 2003–12 | date = October 2007 | pmid = 17658244 | doi = 10.1016/j.cellsig.2007.05.013 }}
| citations =  
* {{cite journal | vauthors = Petrova TV, Makinen T, Alitalo K | title = Signaling via vascular endothelial growth factor receptors | journal = Experimental Cell Research | volume = 253 | issue = 1 | pages = 117–30 | date = November 1999 | pmid = 10579917 | doi = 10.1006/excr.1999.4707 }}
*{{cite journal | author=Petrova TV, Makinen T, Alitalo K |title=Signaling via vascular endothelial growth factor receptors. |journal=Exp. Cell Res. |volume=253 |issue= 1 |pages= 117-30 |year= 1999 |pmid= 10579917 |doi= 10.1006/excr.1999.4707 }}
* {{cite journal | vauthors = Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J | title = Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia | journal = Behavioural Brain Research | volume = 265 | pages = 171–80 | date = May 2014 | pmid = 24589546 | pmc = 4000455 | doi = 10.1016/j.bbr.2014.02.033 }}
*{{cite journal | author=Sato Y, Kanno S, Oda N, ''et al.'' |title=Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. |journal=Ann. N. Y. Acad. Sci. |volume=902 |issue= |pages= 201-5; discussion 205-7 |year= 2000 |pmid= 10865839 |doi= }}
* {{cite journal | vauthors = Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M | title = Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction | journal = Annals of the New York Academy of Sciences | volume = 902 | issue = 1 | pages = 201–5; discussion 205-7 | date = May 2000 | pmid = 10865839 | doi = 10.1111/j.1749-6632.2000.tb06314.x | bibcode = 2000NYASA.902..201S }}
*{{cite journal | author=Zachary I, Gliki G |title=Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. |journal=Cardiovasc. Res. |volume=49 |issue= 3 |pages= 568-81 |year= 2001 |pmid= 11166270 |doi= }}
* {{cite journal | vauthors = Zachary I, Gliki G | title = Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family | journal = Cardiovascular Research | volume = 49 | issue = 3 | pages = 568–81 | date = February 2001 | pmid = 11166270 | doi = 10.1016/S0008-6363(00)00268-6 }}
*{{cite journal | author=Vené R, Benelli R, Noonan DM, Albini A |title=HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis. |journal=Clin. Exp. Metastasis |volume=18 |issue= 7 |pages= 533-8 |year= 2001 |pmid= 11688957 |doi= }}
* {{cite journal | vauthors = Vené R, Benelli R, Noonan DM, Albini A | title = HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis | journal = Clinical & Experimental Metastasis | volume = 18 | issue = 7 | pages = 533–8 | year = 2001 | pmid = 11688957 | doi = 10.1023/A:1011991906685 }}
*{{cite journal | author=Lenton K |title=VEGFR-2 (KDR/Flk-1). |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 227-32 |year= 2003 |pmid= 12456025 |doi=  }}
* {{cite journal | vauthors = Lenton K | title = VEGFR-2 (KDR/Flk-1) | journal = Journal of Biological Regulators and Homeostatic Agents | volume = 16 | issue = 3 | pages = 227–32 | year = 2003 | pmid = 12456025 | doi =  }}
*{{cite journal | author=Matsumoto T, Mugishima H |title=Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis. |journal=J. Atheroscler. Thromb. |volume=13 |issue= 3 |pages= 130-5 |year= 2006 |pmid= 16835467 |doi= }}
* {{cite journal | vauthors = Matsumoto T, Mugishima H | title = Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis | journal = Journal of Atherosclerosis and Thrombosis | volume = 13 | issue = 3 | pages = 130–5 | date = June 2006 | pmid = 16835467 | doi = 10.5551/jat.13.130 }}
}}
{{refend}}
{{refend}}


== External links ==
* {{MeshName|Kinase+insert+domain+receptor}}
{{NLM content}}
{{PDB Gallery|geneid=3791}}
{{Clusters of differentiation}}
{{Growth factor receptors}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Growth factor receptor modulators}}
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{{DEFAULTSORT:Kinase Insert Domain Receptor}}
[[Category:Clusters of differentiation]]
[[Category:Tyrosine kinase receptors]]
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Latest revision as of 12:01, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.[1]


Interactions

Kinase insert domain receptor has been shown to interact with SHC2,[2] Annexin A5[3] and SHC1.[4][5]

See also

References

  1. ↑ Glubb DM, Cerri E, Giese A, Zhang W, Mirza O, Thompson EE, Chen P, Das S, Jassem J, Rzyman W, Lingen MW, Salgia R, Hirsch FR, Dziadziuszko R, Ballmer-Hofer K, Innocenti F (August 2011). "Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer". Clinical Cancer Research. 17 (16): 5257–67. doi:10.1158/1078-0432.CCR-11-0379. PMC 3156871. PMID 21712447.
  2. ↑ Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". The Biochemical Journal. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983. PMID 10749680.
  3. ↑ Wen Y, Edelman JL, Kang T, Sachs G (May 1999). "Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1". Biochemical and Biophysical Research Communications. 258 (3): 713–21. doi:10.1006/bbrc.1999.0678. PMID 10329451.
  4. ↑ Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M, Lanfrancone L, Dejana E (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (4): 617–22. doi:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700.
  5. ↑ D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Molecular Endocrinology. 13 (5): 692–704. doi:10.1210/mend.13.5.0280. PMID 10319320.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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