The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
In the development of forebrain, cortical patterning centers are the boundaries or poles of cortical primordium, where multiple BMP and WNT genes are expressed. Besides, at the anterior pole several FGF family including Fgf3, 8,17 and 18 overlap in expression. The similarity in cortical gene expression in Emx2 mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the graded expression(low anterior, high posterior) of Emx2 in the cortical primordium. Emx2 is one of the protomap molecular determinants that prove to be closely interacted with Pax6. Emx2 and Pax6 are expressed in opposing gradients along the A/P axis of the cortical primordium and cooperate to set up area pattern. Fgf8 and Emx2 antagonize each other to create the development map. Fgf8 promotes the development of anterior part and suppresses posterior fate, while the Emx2 does the reverse. What's more, FGF8 manipulations suggest FGF8 controls the cortical graded expression of COUP-TF1. Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary specification.Thus, the interaction between them regulates the A/P axis of cortical primordium and directs the development map of cortical area.
This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs reveal roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
↑White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (Apr 1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID8595889.
Tanaka A, Miyamoto K, Matsuo H, et al. (1995). "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties". FEBS Lett. 363 (3): 226–30. doi:10.1016/0014-5793(95)00324-3. PMID7737407.
Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (2000). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". J. Biol. Chem. 274 (49): 34785–94. doi:10.1074/jbc.274.49.34785. PMID10574949.
Loo BB, Darwish KK, Vainikka SS, et al. (2001). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. PMID10736564.
Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43. PMID10751172.
Tanaka S, Ueo H, Mafune K, et al. (2001). "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". Dig. Dis. Sci. 46 (5): 1016–21. doi:10.1023/A:1010753826788. PMID11341643.
Ruohola JK, Viitanen TP, Valve EM, et al. (2001). "Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells". Cancer Res. 61 (10): 4229–37. PMID11358849.
Mattila MM, Ruohola JK, Valve EM, et al. (2001). "FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells". Oncogene. 20 (22): 2791–804. doi:10.1038/sj.onc.1204430. PMID11420691.
Gnanapragasam VJ, Robson CN, Neal DE, Leung HY (2002). "Regulation of FGF8 expression by the androgen receptor in human prostate cancer". Oncogene. 21 (33): 5069–80. doi:10.1038/sj.onc.1205663. PMID12140757.