Complement receptor 2
| Complement component (3d/Epstein Barr virus) receptor 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1ghq. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | CR2 ; C3DR; CD21 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55611 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | n/a | n/a | |||||||||||
| Ensembl | n/a | n/a | |||||||||||
| UniProt | n/a | n/a | |||||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
Complement component (3d/Epstein Barr virus) receptor 2, also known as CR2 and CD21, is a protein involved in the complement system. It binds to C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation [1]
Complement component receptor-2 (CR2) is the membrane protein on B lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. See also MIM 120620. Yefenof et al. (1976) found complete overlapping of EBV receptors and C3 (MIM 120700) receptors on human B lymphocytes.[supplied by OMIM][1]
References
Further reading
- Cooper NR, Bradt BM, Rhim JS, Nemerow GR (1990). "CR2 complement receptor". J. Invest. Dermatol. 94 (6 Suppl): 112S–117S. PMID 2161885.
- Yefenof E, Klein G, Jondal M, Oldstone MB (1976). "Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines". Int. J. Cancer. 17 (6): 693–700. PMID 181330.
- Gauffre A, Viron A, Barel M; et al. (1992). "Nuclear localization of the Epstein-Barr virus/C3d receptor (CR2) in the human Burkitt B lymphoma cell, Raji". Mol. Immunol. 29 (9): 1113–20. PMID 1323059.
- Bradbury LE, Kansas GS, Levy S; et al. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules". J. Immunol. 149 (9): 2841–50. PMID 1383329.
- Levy E, Ambrus J, Kahl L; et al. (1992). "T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE)". Clin. Exp. Immunol. 90 (2): 235–44. PMID 1424280.
- Matsumoto AK, Kopicky-Burd J, Carter RH; et al. (1991). "Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19". J. Exp. Med. 173 (1): 55–64. PMID 1702139.
- Tuveson DA, Ahearn JM, Matsumoto AK, Fearon DT (1991). "Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex". J. Exp. Med. 173 (5): 1083–9. PMID 1708808.
- Kalli KR, Ahearn JM, Fearon DT (1991). "Interaction of iC3b with recombinant isotypic and chimeric forms of CR2". J. Immunol. 147 (2): 590–4. PMID 1830068.
- Barel M, Gauffre A, Lyamani F; et al. (1991). "Intracellular interaction of EBV/C3d receptor (CR2) with p68, a calcium-binding protein present in normal but not in transformed B lymphocytes". J. Immunol. 147 (4): 1286–91. PMID 1831222.
- Delcayre AX, Salas F, Mathur S; et al. (1991). "Epstein Barr virus/complement C3d receptor is an interferon alpha receptor". EMBO J. 10 (4): 919–26. PMID 1849076.
- Kurtz CB, Paul MS, Aegerter M; et al. (1989). "Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry". J. Immunol. 143 (6): 2058–67. PMID 2528587.
- Fujisaku A, Harley JB, Frank MB; et al. (1989). "Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor". J. Biol. Chem. 264 (4): 2118–25. PMID 2563370.
- Moore MD, Cooper NR, Tack BF, Nemerow GR (1988). "Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9194–8. PMID 2827171.
- Weis JJ, Toothaker LE, Smith JA; et al. (1988). "Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins". J. Exp. Med. 167 (3): 1047–66. PMID 2832506.
- Weis JJ, Fearon DT, Klickstein LB; et al. (1986). "Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement". Proc. Natl. Acad. Sci. U.S.A. 83 (15): 5639–43. PMID 3016712.
- Weis JH, Morton CC, Bruns GA; et al. (1987). "A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32". J. Immunol. 138 (1): 312–5. PMID 3782802.
- Aubry JP, Pochon S, Gauchat JF; et al. (1994). "CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21". J. Immunol. 152 (12): 5806–13. PMID 7515913.
- Matsumoto AK, Martin DR, Carter RH; et al. (1993). "Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes". J. Exp. Med. 178 (4): 1407–17. PMID 7690834.
- Barel M, Balbo M, Gauffre A, Frade R (1995). "Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein". Mol. Immunol. 32 (6): 389–97. PMID 7753047.
See also
External links
- Complement+Receptors+2 at the US National Library of Medicine Medical Subject Headings (MeSH)
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |