CD14

CD14 molecule
Identifiers
Symbols	CD14 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 493
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CD14 is a membrane-associated glycosylphosphatidylinositol-linked protein expressed at the surface of cells, especially macrophages.

CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins.

CD14 was the first described pattern recognition receptor.

Function

CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Production

A soluble form sCD14 is secreted by the liver and monocytes and is sufficient in low concentrations to confer LPS-responsiveness to cells which otherwise do not express CD14.

Differentiation

CD14+ are monocytes that can differentiate into a host of different cells. (A '+' sign refers to the presence of the CD14 protein on a cell. )

One type of cell is the dendritic cell, where differentiation is encouraged by cytokines. Examples of cytokines that will cause dendritic cell differentiation includes GM-CSF and IL-4.

External links

• CD14+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Todd RF, Petty HR (1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors". J. Lab. Clin. Med. 129 (5): 492–8. PMID 9142045.