FCGR3A: Difference between revisions

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{{Infobox_gene}}
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'''Low affinity immunoglobulin gamma Fc region receptor III-A''' is a [[protein]] that in humans is encoded by the ''FCGR3A'' [[gene]].<ref name="pmid2139735">{{cite journal | vauthors = Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV | title = Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination | journal = Science | volume = 248 | issue = 4956 | pages = 732–5 | date = May 1990 | pmid = 2139735 | pmc =  | doi = 10.1126/science.2139735 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2214| accessdate = }}</ref> It is also known as CD16a as it is part of the [[cluster of differentiation]] cell surface molecules.
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{{GNF_Protein_box
| image = PBB_Protein_FCGR3A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e4j.
| PDB = {{PDB2|1e4j}}, {{PDB2|1e4k}}, {{PDB2|1fnl}}, {{PDB2|1iis}}, {{PDB2|1iix}}, {{PDB2|1t83}}, {{PDB2|1t89}}
| Name = Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
| HGNCid = 3619
| Symbol = FCGR3A
| AltSymbols =; CD16; CD16a; FCG3; FCGR3; IGFR3
| OMIM = 146740
| ECnumber = 
| Homologene = 477
| MGIid = 2179523
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0019864 |text = IgG binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2214
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001133750
    | Hs_RefseqmRNA = XM_001133750
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 246256
    | Mm_Ensembl = ENSMUSG00000059089
    | Mm_RefseqmRNA = NM_144559
    | Mm_RefseqProtein = NP_653142
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 172855601
    | Mm_GenLoc_end = 172866436
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}}
'''Fc fragment of IgG, low affinity IIIa, receptor (CD16a)''', also known as '''FCGR3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2214| accessdate = }}</ref>


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== References ==
{{PBB_Summary
{{reflist}}
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==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF | title = Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 6 | pages = 2274–8 | date = March 1990 | pmid = 2138330 | pmc = 53669 | doi = 10.1073/pnas.87.6.2274 }}
| citations =
* {{cite journal | vauthors = Le Coniat M, Kinet JP, Berger R | title = The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23 | journal = Immunogenetics | volume = 32 | issue = 3 | pages = 183–6 | year = 1990 | pmid = 2146219 | doi = 10.1007/BF02114971 }}
*{{cite journal | author=Anderson P, Caligiuri M, O'Brien C, ''et al.'' |title=Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 6 |pages= 2274-8 |year= 1990 |pmid= 2138330 |doi= }}
* {{cite journal | vauthors = Ory PA, Clark MR, Kwoh EE, Clarkson SB, Goldstein IM | title = Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils | journal = The Journal of Clinical Investigation | volume = 84 | issue = 5 | pages = 1688–91 | date = November 1989 | pmid = 2478590 | pmc = 304039 | doi = 10.1172/JCI114350 }}
*{{cite journal | author=Qiu WQ, de Bruin D, Brownstein BH, ''et al.'' |title=Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. |journal=Science |volume=248 |issue= 4956 |pages= 732-5 |year= 1990 |pmid= 2139735 |doi= }}
* {{cite journal | vauthors = Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW | title = Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 3 | pages = 1013–7 | date = February 1989 | pmid = 2521732 | pmc = 286611 | doi = 10.1073/pnas.86.3.1013 }}
*{{cite journal | author=Le Coniat M, Kinet JP, Berger R |title=The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23. |journal=Immunogenetics |volume=32 |issue= 3 |pages= 183-6 |year= 1990 |pmid= 2146219 |doi= }}
* {{cite journal | vauthors = Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP | title = A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 13 | pages = 5079–83 | date = July 1989 | pmid = 2525780 | pmc = 297560 | doi = 10.1073/pnas.86.13.5079 }}
*{{cite journal | author=Ory PA, Clark MR, Kwoh EE, ''et al.'' |title=Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils. |journal=J. Clin. Invest. |volume=84 |issue= 5 |pages= 1688-91 |year= 1989 |pmid= 2478590 |doi= }}
* {{cite journal | vauthors = Ravetch JV, Perussia B | title = Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions | journal = The Journal of Experimental Medicine | volume = 170 | issue = 2 | pages = 481–97 | date = August 1989 | pmid = 2526846 | pmc = 2189395 | doi = 10.1084/jem.170.2.481 }}
*{{cite journal | author=Peltz GA, Grundy HO, Lebo RV, ''et al.'' |title=Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 3 |pages= 1013-7 |year= 1989 |pmid= 2521732 |doi= }}
* {{cite journal | vauthors = Simmons D, Seed B | title = The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein | journal = Nature | volume = 333 | issue = 6173 | pages = 568–70 | date = June 1988 | pmid = 2967436 | doi = 10.1038/333568a0 }}
*{{cite journal | author=Scallon BJ, Scigliano E, Freedman VH, ''et al.'' |title=A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 13 |pages= 5079-83 |year= 1989 |pmid= 2525780 |doi= }}
* {{cite journal | vauthors = Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD | title = The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI | journal = Experimental Hematology | volume = 22 | issue = 7 | pages = 599–606 | date = July 1994 | pmid = 7516890 | doi = }}
*{{cite journal | author=Ravetch JV, Perussia B |title=Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. |journal=J. Exp. Med. |volume=170 |issue= 2 |pages= 481-97 |year= 1989 |pmid= 2526846 |doi= }}
* {{cite journal | vauthors = Detmers PA, Zhou D, Powell D, Lichenstein H, Kelley M, Pironkova R | title = Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase | journal = Journal of Immunology | volume = 155 | issue = 4 | pages = 2085–95 | date = August 1995 | pmid = 7543538 | doi =  }}
*{{cite journal | author=Simmons D, Seed B |title=The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein. |journal=Nature |volume=333 |issue= 6173 |pages= 568-70 |year= 1988 |pmid= 2967436 |doi= 10.1038/333568a0 }}
* {{cite journal | vauthors = Morcos M, Hänsch GM, Schönermark M, Ellwanger S, Härle M, Heckl-Ostreicher B | title = Human glomerular mesangial cells express CD16 and may be stimulated via this receptor | journal = Kidney International | volume = 46 | issue = 6 | pages = 1627–34 | date = December 1994 | pmid = 7700021 | doi = 10.1038/ki.1994.462 }}
*{{cite journal | author=Indik ZK, Hunter S, Huang MM, ''et al.'' |title=The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI. |journal=Exp. Hematol. |volume=22 |issue= 7 |pages= 599-606 |year= 1994 |pmid= 7516890 |doi=  }}
* {{cite journal | vauthors = Schumann G, Dasgupta JD | title = Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif | journal = International Immunology | volume = 6 | issue = 9 | pages = 1383–92 | date = September 1994 | pmid = 7819147 | doi = 10.1093/intimm/6.9.1383 }}
*{{cite journal | author=Detmers PA, Zhou D, Powell D, ''et al.'' |title=Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase. |journal=J. Immunol. |volume=155 |issue= 4 |pages= 2085-95 |year= 1995 |pmid= 7543538 |doi= }}
* {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE | title = The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions | journal = The Journal of Biological Chemistry | volume = 270 | issue = 3 | pages = 1350–61 | date = January 1995 | pmid = 7836402 | doi = 10.1074/jbc.270.3.1350 }}
*{{cite journal | author=Morcos M, Hänsch GM, Schönermark M, ''et al.'' |title=Human glomerular mesangial cells express CD16 and may be stimulated via this receptor. |journal=Kidney Int. |volume=46 |issue= 6 |pages= 1627-34 |year= 1995 |pmid= 7700021 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Schumann G, Dasgupta JD |title=Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif. |journal=Int. Immunol. |volume=6 |issue= 9 |pages= 1383-92 |year= 1995 |pmid= 7819147 |doi= }}
* {{cite journal | vauthors = Altin JG, Pagler EB, Kinnear BF, Warren HS | title = Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells | journal = Immunology and Cell Biology | volume = 72 | issue = 1 | pages = 87–96 | date = February 1994 | pmid = 8157290 | doi = 10.1038/icb.1994.13 }}
*{{cite journal | author=Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE |title=The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. |journal=J. Biol. Chem. |volume=270 |issue= 3 |pages= 1350-61 |year= 1995 |pmid= 7836402 |doi= }}
* {{cite journal | vauthors = Pignata C, Prasad KV, Robertson MJ, Levine H, Rudd CE, Ritz J | title = Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells | journal = Journal of Immunology | volume = 151 | issue = 12 | pages = 6794–800 | date = December 1993 | pmid = 8258691 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Cone JC, Lu Y, Trevillyan JM, Bjorndahl JM, Phillips CA | title = Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells | journal = European Journal of Immunology | volume = 23 | issue = 10 | pages = 2488–97 | date = October 1993 | pmid = 8405050 | doi = 10.1002/eji.1830231017 }}
*{{cite journal | author=Altin JG, Pagler EB, Kinnear BF, Warren HS |title=Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells. |journal=Immunol. Cell Biol. |volume=72 |issue= 1 |pages= 87-96 |year= 1994 |pmid= 8157290 |doi=  }}
* {{cite journal | vauthors = de Haas M, Koene HR, Kleijer M, de Vries E, Simsek S, van Tol MJ, Roos D, von dem Borne AE | title = A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa | journal = Journal of Immunology | volume = 156 | issue = 8 | pages = 2948–55 | date = April 1996 | pmid = 8609432 | doi =  }}
*{{cite journal | author=Pignata C, Prasad KV, Robertson MJ, ''et al.'' |title=Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells. |journal=J. Immunol. |volume=151 |issue= 12 |pages= 6794-800 |year= 1994 |pmid= 8258691 |doi= }}
* {{cite journal | vauthors = Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE | title = Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene | journal = The Journal of Biological Chemistry | volume = 271 | issue = 48 | pages = 30755–64 | date = November 1996 | pmid = 8940055 | doi = 10.1074/jbc.271.48.30755 }}
*{{cite journal | author=Cone JC, Lu Y, Trevillyan JM, ''et al.'' |title=Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells. |journal=Eur. J. Immunol. |volume=23 |issue= 10 |pages= 2488-97 |year= 1993 |pmid= 8405050 |doi=  }}
* {{cite journal | vauthors = Koene HR, Kleijer M, Algra J, Roos D, von dem Borne AE, de Haas M | title = Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype | journal = Blood | volume = 90 | issue = 3 | pages = 1109–14 | date = August 1997 | pmid = 9242542 | doi =  }}
*{{cite journal | author=de Haas M, Koene HR, Kleijer M, ''et al.'' |title=A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa. |journal=J. Immunol. |volume=156 |issue= 8 |pages= 3948-55 |year= 1996 |pmid= 8609432 |doi= }}
* {{cite journal | vauthors = Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK | title = The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms | journal = Blood Coagulation & Fibrinolysis | volume = 23 | issue = 1 | pages = 45–50 | date = January 2012 | pmid = 22024796 | doi = 10.1097/mbc.0b013e32834d7ce3 }}
*{{cite journal | author=Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE |title=Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30755-64 |year= 1997 |pmid= 8940055 |doi=  }}
* {{cite journal | vauthors = Keane C, Nourse JP, Crooks P, Nguyen-Van D, Mutsando H, Mollee P, Lea RA, Gandhi MK | title = Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma | journal = Internal Medicine Journal | volume = 42 | issue = 10 | pages = 1113–9 | date = October 2012 | pmid = 21883784 | doi = 10.1111/j.1445-5994.2011.02587.x }}
*{{cite journal | author=Koene HR, Kleijer M, Algra J, ''et al.'' |title=Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype. |journal=Blood |volume=90 |issue= 3 |pages= 1109-14 |year= 1997 |pmid= 9242542 |doi= }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2214}}


{{protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Fc receptors]]
 
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{{immunology-stub}}

Revision as of 03:05, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.[1][2] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.


References

  1. ↑ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
  2. ↑ "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)".

Further reading

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