LILRB3: Difference between revisions

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{{Infobox_gene}}
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'''Leukocyte immunoglobulin-like receptor subfamily B member 3''' is a [[protein]] that in humans is encoded by the ''LILRB3'' [[gene]].<ref name="pmid9278324">{{cite journal |vauthors=Arm JP, Nwankwo C, Austen KF | title = Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor | journal = J Immunol | volume = 159 | issue = 5 | pages = 2342–9 |date=Sep 1997 | pmid = 9278324 | pmc = | doi = }}</ref><ref name="pmid9382880">{{cite journal |vauthors=Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M | title = A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells | journal = J Exp Med | volume = 186 | issue = 11 | pages = 1809–18 |date=Dec 1997 | pmid = 9382880 | pmc = 2199153 | doi =10.1084/jem.186.11.1809 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
| HGNCid = 6607
| Symbol = LILRB3
| AltSymbols =; CD85A; HL9; ILT5; LIR-3; LIR3; MGC138403
| OMIM = 604820
| ECnumber = 
| Homologene = 40761
| MGIid = 1195971
| GeneAtlas_image1 = PBB_GE_LILRB3_208594_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_LILRB3_210784_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_LILRB3_210225_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11025
    | Hs_Ensembl = ENSG00000186152
    | Hs_RefseqProtein = NP_001074919
    | Hs_RefseqmRNA = NM_001081450
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 59412565
    | Hs_GenLoc_end = 59418660
    | Hs_Uniprot = O75022
    | Mm_EntrezGene = 18722
    | Mm_Ensembl = ENSMUSG00000030427
    | Mm_RefseqmRNA = NM_011087
    | Mm_RefseqProtein = NP_035217
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 3511702
    | Mm_GenLoc_end = 3518590
    | Mm_Uniprot = 
  }}
}}
'''Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3''', also known as '''LILRB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025| accessdate = }}</ref>
| summary_text = This gene is a member of the [[leukocyte immunoglobulin-like receptor]] (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Sloane DE, Tedla N, Awoniyi M, ''et al.'' |title=Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. |journal=Blood |volume=104 |issue= 9 |pages= 2832-9 |year= 2004 |pmid= 15242876 |doi= 10.1182/blood-2004-01-0268 }}
*{{cite journal   |vauthors=Sloane DE, Tedla N, Awoniyi M, etal |title=Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. |journal=Blood |volume=104 |issue= 9 |pages= 2832–9 |year= 2004 |pmid= 15242876 |doi= 10.1182/blood-2004-01-0268 }}
*{{cite journal | author=Tedla N, Bandeira-Melo C, Tassinari P, ''et al.'' |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174-9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 }}
*{{cite journal   |vauthors=Tedla N, Bandeira-Melo C, Tassinari P, etal |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 | pmc=298746 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Wende H, Volz A, Ziegler A |title=Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 703-13 |year= 2000 |pmid= 10941842 |doi=  }}
*{{cite journal  |vauthors=Wende H, Volz A, Ziegler A |title=Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 703–13 |year= 2000 |pmid= 10941842 |doi=10.1007/s002510000187 }}
*{{cite journal | author=Borges L, Hsu ML, Fanger N, ''et al.'' |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192-6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal   |vauthors=Borges L, Hsu ML, Fanger N, etal |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192–6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal | author=Colonna M, Navarro F, Bellón T, ''et al.'' |title=A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. |journal=J. Exp. Med. |volume=186 |issue= 11 |pages= 1809-18 |year= 1997 |pmid= 9382880 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Cella M, Döhring C, Samaridis J, etal |title=A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. |journal=J. Exp. Med. |volume=185 |issue= 10 |pages= 1743–51 |year= 1997 |pmid= 9151699 |doi=10.1084/jem.185.10.1743  | pmc=2196312 }}
*{{cite journal  | author=Arm JP, Nwankwo C, Austen KF |title=Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. |journal=J. Immunol. |volume=159 |issue= 5 |pages= 2342-9 |year= 1997 |pmid= 9278324 |doi= }}
*{{cite journal  |vauthors=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660–5 |year= 1997 |pmid= 9079806 |doi=10.1002/eji.1830270313 }}
*{{cite journal | author=Cella M, Döhring C, Samaridis J, ''et al.'' |title=A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. |journal=J. Exp. Med. |volume=185 |issue= 10 |pages= 1743-51 |year= 1997 |pmid= 9151699 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660-5 |year= 1997 |pmid= 9079806 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
}}
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* {{MeshName|LILRB3+protein,+human}}
* {{MeshName|LILRB3+protein,+human}}


{{membrane-protein-stub}}
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{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Immunoglobulin superfamily]]
 
 
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Latest revision as of 17:56, 2 September 2017

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External IDsGeneCards: [1]
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SpeciesHumanMouse
Entrez

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RefSeq (protein)

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Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

See also

References

  1. ↑ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol. 159 (5): 2342–9. PMID 9278324.
  2. ↑ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J Exp Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
  3. ↑ 3.0 3.1 "Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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