KIR2DL1: Difference between revisions

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Latest revision as of 06:29, 2 September 2017

Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.^[1]^[2]^[3]

Function

Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.^[3]

Interactions

KIR2DL1 has been shown to interact with HLA-C.^[4]^[5]^[6]^[7]

References

↑ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (June 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
↑ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543.
↑ ^3.0 ^3.1 "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".
↑ Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.
↑ Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (December 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
↑ Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
↑ Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700.

Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC (1997). "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors". Nature. 389 (6646): 96–100. doi:10.1038/38028. PMID 9288975.
Kim J, Chwae YJ, Kim MY, Choi IH, Park JH, Kim SJ (1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875–82. PMID 9378975.
Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors". Immunity. 7 (6): 739–51. doi:10.1016/S1074-7613(00)80393-3. PMID 9430220.
Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P (1998). "Human diversity in killer cell inhibitory receptor genes". Immunity. 7 (6): 753–63. doi:10.1016/S1074-7613(00)80394-5. PMID 9430221.
Rajagopalan S, Long EO (1998). "Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells". J. Immunol. 161 (3): 1299–305. PMID 9686591.
Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
Shilling HG, Lienert-Weidenbach K, Valiante NM, Uhrberg M, Parham P (1998). "Evidence for recombination as a mechanism for KIR diversification". Immunogenetics. 48 (6): 413–6. doi:10.1007/s002510050453. PMID 9799338.
Chwae YJ, Cho SE, Kim SJ, Kim J (1999). "Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual". Immunol. Lett. 68 (2–3): 267–74. doi:10.1016/S0165-2478(99)00062-0. PMID 10424431.
Fan QR, Wiley DC (1999). "Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor". J. Exp. Med. 190 (1): 113–23. doi:10.1084/jem.190.1.113. PMC 2195553. PMID 10429675.
Richardson J, Reyburn HT, Luque I, Valés-Gómez M, Strominger JL (2000). "Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site". Eur. J. Immunol. 30 (5): 1480–5. doi:10.1002/(SICI)1521-4141(200005)30:5<1480::AID-IMMU1480>3.0.CO;2-7. PMID 10820396.
Fan QR, Long EO, Wiley DC (2000). "A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer". Eur. J. Immunol. 30 (9): 2692–7. doi:10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0. PMID 11009104.
Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (2001). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens. 57 (1): 22–31. doi:10.1034/j.1399-0039.2001.057001022.x. PMID 11169255.
Fan QR, Long EO, Wiley DC (2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700.
Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard A (2002). "Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction". Blood. 100 (8): 2874–81. doi:10.1182/blood-2002-02-0643. PMID 12351398.
Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A (2003). "Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction". Blood. 100 (12): 4098–107. doi:10.1182/blood-2002-04-1284. PMID 12393468.
Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (2003). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid7749980-1] Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (June 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.

[pmid7716543-2] Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543.

[entrez-3] 3.0 ^3.1 "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".

[pmid12454284-4] Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.

[pmid11163076-5] Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (December 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.

[pmid9768753-6] Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.

[pmid11323700-7] Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Killer cell immunoglobulin-like receptor 2DL1''' is a [[protein]] that in humans is encoded by the ''KIR2DL1'' [[gene]].<ref name="pmid7749980">{{cite journal | vauthors = Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO | title = Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains | journal = Immunity | volume = 2 | issue = 5 | pages = 439–49 | date = June 1995 | pmid = 7749980 | pmc =  | doi = 10.1016/1074-7613(95)90025-X }}</ref><ref name="pmid7716543">{{cite journal | vauthors = Colonna M, Samaridis J | title = Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells | journal = Science | volume = 268 | issue = 5209 | pages = 405–8 | date = May 1995 | pmid = 7716543 | pmc =  | doi = 10.1126/science.7716543 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_KIR2DL1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b6u.
- | PDB = {{PDB2|1b6u}}, {{PDB2|1efx}}, {{PDB2|1im9}}, {{PDB2|1m4k}}, {{PDB2|1nkr}}, {{PDB2|2dl2}}, {{PDB2|2dli}}
- | Name = Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
- | HGNCid = 6329
- | Symbol = KIR2DL1
- | AltSymbols =; 47.11; CD158A; CL-42; KIR-K3; KIR-K64; KIR-K65; KIR-K9; KIR221; NKAT; NKAT1; p58.1; CD158B1; CD158k; CL-43; NKAT6; p58.2; p58; CL-6; CD158B2; CD158b; GL183; KIR-023GB; KIR-K15; KIR-K7c; MGC129943; NKAT2; NKAT2A; NKAT2B; NKR-K7; p58 KIR; CD158H; EB6ActI; EB6ActII; p50.1; KIR2DL3; 183ACTI; CD158J; CL-49; MGC120018; NKAT5; p50.2; NKAT7; 1060P11.7; CD158G; NKAT9
- | OMIM = 604936
- | ECnumber =
- | Homologene = 74998
- | MGIid =
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0030110 |text = HLA-C specific inhibitory MHC class I receptor activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003823 |text = antigen binding}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0005575 |text = cellular_component}}
- | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3802
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_055033
-    | Hs_RefseqmRNA = NM_014218
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1''', also known as '''KIR2DL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Killer-cell immunoglobulin-like receptors]] (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb [[leukocyte receptor complex]] (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several &quot;framework&quot; genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>
-}}
-==See also==
+== Interactions ==
+KIR2DL1 has been shown to [[Protein-protein interaction|interact]] with [[HLA-C]].<ref name=pmid12454284>{{cite journal | vauthors = Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL | title = Disulfide bond-mediated dimerization of HLA-G on the cell surface | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 99 | issue = 25 | pages = 16180–5 | date = December 2002 | pmid = 12454284 | pmc = 138585 | doi = 10.1073/pnas.212643199 }}</ref><ref name=pmid11163076>{{cite journal | vauthors = Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL | title = N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors | journal = Hum. Immunol. | volume = 61 | issue = 12 | pages = 1202–18 | date = December 2000 | pmid = 11163076 | doi = 10.1016/S0198-8859(00)00184-1 }}</ref><ref name=pmid9768753>{{cite journal | vauthors = Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL | title = Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors | journal = Immunity | volume = 9 | issue = 3 | pages = 337–44 | date = September 1998 | pmid = 9768753 | doi = 10.1016/S1074-7613(00)80616-0 }}</ref><ref name=pmid11323700>{{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex | journal = Nat. Immunol. | volume = 2 | issue = 5 | pages = 452–60 | date = May 2001 | pmid = 11323700 | doi = 10.1038/87766 }}</ref>
+== See also ==
 * [[Cluster of differentiation]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC | title = Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors | journal = Nature | volume = 389 | issue = 6646 | pages = 96–100 | year = 1997 | pmid = 9288975 | doi = 10.1038/38028 }}
-| citations =
+* {{cite journal | vauthors = Kim J, Chwae YJ, Kim MY, Choi IH, Park JH, Kim SJ | title = Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors | journal = J. Immunol. | volume = 159 | issue = 8 | pages = 3875–82 | year = 1997 | pmid = 9378975 | doi =  }}
-*{{cite journal  | author=Colonna M, Samaridis J |title=Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. |journal=Science |volume=268 |issue= 5209 |pages= 405-8 |year= 1995 |pmid= 7716543 |doi=  }}
+* {{cite journal | vauthors = Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P | title = Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors | journal = Immunity | volume = 7 | issue = 6 | pages = 739–51 | year = 1998 | pmid = 9430220 | doi = 10.1016/S1074-7613(00)80393-3 }}
-*{{cite journal  | author=Wagtmann N, Biassoni R, Cantoni C, ''et al.'' |title=Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. |journal=Immunity |volume=2 |issue= 5 |pages= 439-49 |year= 1995 |pmid= 7749980 |doi=  }}
+* {{cite journal | vauthors = Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P | title = Human diversity in killer cell inhibitory receptor genes | journal = Immunity | volume = 7 | issue = 6 | pages = 753–63 | year = 1998 | pmid = 9430221 | doi = 10.1016/S1074-7613(00)80394-5 }}
-*{{cite journal  | author=Fan QR, Mosyak L, Winter CC, ''et al.'' |title=Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. |journal=Nature |volume=389 |issue= 6646 |pages= 96-100 |year= 1997 |pmid= 9288975 |doi= 10.1038/38028 }}
+* {{cite journal | vauthors = Rajagopalan S, Long EO | title = Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells | journal = J. Immunol. | volume = 161 | issue = 3 | pages = 1299–305 | year = 1998 | pmid = 9686591 | doi =  }}
-*{{cite journal  | author=Kim J, Chwae YJ, Kim MY, ''et al.'' |title=Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 3875-82 |year= 1997 |pmid= 9378975 |doi=  }}
+* {{cite journal | vauthors = Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL | title = Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors | journal = Immunity | volume = 9 | issue = 3 | pages = 337–44 | year = 1998 | pmid = 9768753 | doi = 10.1016/S1074-7613(00)80616-0 }}
-*{{cite journal  | author=Valiante NM, Uhrberg M, Shilling HG, ''et al.'' |title=Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. |journal=Immunity |volume=7 |issue= 6 |pages= 739-51 |year= 1998 |pmid= 9430220 |doi=  }}
+* {{cite journal | vauthors = Shilling HG, Lienert-Weidenbach K, Valiante NM, Uhrberg M, Parham P | title = Evidence for recombination as a mechanism for KIR diversification | journal = Immunogenetics | volume = 48 | issue = 6 | pages = 413–6 | year = 1998 | pmid = 9799338 | doi = 10.1007/s002510050453 }}
-*{{cite journal  | author=Uhrberg M, Valiante NM, Shum BP, ''et al.'' |title=Human diversity in killer cell inhibitory receptor genes. |journal=Immunity |volume=7 |issue= 6 |pages= 753-63 |year= 1998 |pmid= 9430221 |doi=  }}
+* {{cite journal | vauthors = Chwae YJ, Cho SE, Kim SJ, Kim J | title = Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual | journal = Immunol. Lett. | volume = 68 | issue = 2–3 | pages = 267–74 | year = 1999 | pmid = 10424431 | doi = 10.1016/S0165-2478(99)00062-0 }}
-*{{cite journal  | author=Rajagopalan S, Long EO |title=Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. |journal=J. Immunol. |volume=161 |issue= 3 |pages= 1299-305 |year= 1998 |pmid= 9686591 |doi=  }}
+* {{cite journal | vauthors = Fan QR, Wiley DC | title = Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor | journal = J. Exp. Med. | volume = 190 | issue = 1 | pages = 113–23 | year = 1999 | pmid = 10429675 | pmc = 2195553 | doi = 10.1084/jem.190.1.113 }}
-*{{cite journal  | author=Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL |title=Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. |journal=Immunity |volume=9 |issue= 3 |pages= 337-44 |year= 1998 |pmid= 9768753 |doi=  }}
+* {{cite journal | vauthors = Richardson J, Reyburn HT, Luque I, Valés-Gómez M, Strominger JL | title = Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site | journal = Eur. J. Immunol. | volume = 30 | issue = 5 | pages = 1480–5 | year = 2000 | pmid = 10820396 | doi = 10.1002/(SICI)1521-4141(200005)30:5<1480::AID-IMMU1480>3.0.CO;2-7 }}
-*{{cite journal  | author=Shilling HG, Lienert-Weidenbach K, Valiante NM, ''et al.'' |title=Evidence for recombination as a mechanism for KIR diversification. |journal=Immunogenetics |volume=48 |issue= 6 |pages= 413-6 |year= 1998 |pmid= 9799338 |doi=  }}
+* {{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer | journal = Eur. J. Immunol. | volume = 30 | issue = 9 | pages = 2692–7 | year = 2000 | pmid = 11009104 | doi = 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 }}
-*{{cite journal  | author=Chwae YJ, Cho SE, Kim SJ, Kim J |title=Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual. |journal=Immunol. Lett. |volume=68 |issue= 2-3 |pages= 267-74 |year= 1999 |pmid= 10424431 |doi=  }}
+* {{cite journal | vauthors = Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL | title = N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors | journal = Hum. Immunol. | volume = 61 | issue = 12 | pages = 1202–18 | year = 2001 | pmid = 11163076 | doi = 10.1016/S0198-8859(00)00184-1 }}
-*{{cite journal  | author=Fan QR, Wiley DC |title=Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor. |journal=J. Exp. Med. |volume=190 |issue= 1 |pages= 113-23 |year= 1999 |pmid= 10429675 |doi=  }}
+* {{cite journal | vauthors = Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P | title = Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors | journal = Tissue Antigens | volume = 57 | issue = 1 | pages = 22–31 | year = 2001 | pmid = 11169255 | doi = 10.1034/j.1399-0039.2001.057001022.x }}
-*{{cite journal  | author=Richardson J, Reyburn HT, Luque I, ''et al.'' |title=Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site. |journal=Eur. J. Immunol. |volume=30 |issue= 5 |pages= 1480-5 |year= 2000 |pmid= 10820396 |doi=  }}
+* {{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex | journal = Nat. Immunol. | volume = 2 | issue = 5 | pages = 452–60 | year = 2001 | pmid = 11323700 | doi = 10.1038/87766 }}
-*{{cite journal  | author=Fan QR, Long EO, Wiley DC |title=A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer. |journal=Eur. J. Immunol. |volume=30 |issue= 9 |pages= 2692-7 |year= 2000 |pmid= 11009104 |doi= 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 }}
+* {{cite journal | vauthors = Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard A | title = Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction | journal = Blood | volume = 100 | issue = 8 | pages = 2874–81 | year = 2002 | pmid = 12351398 | doi = 10.1182/blood-2002-02-0643 }}
-*{{cite journal  | author=Baba E, Erskine R, Boyson JE, ''et al.'' |title=N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors. |journal=Hum. Immunol. |volume=61 |issue= 12 |pages= 1202-18 |year= 2001 |pmid= 11163076 |doi=  }}
+* {{cite journal | vauthors = Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A | title = Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction | journal = Blood | volume = 100 | issue = 12 | pages = 4098–107 | year = 2003 | pmid = 12393468 | doi = 10.1182/blood-2002-04-1284 }}
-*{{cite journal  | author=Rajalingam R, Gardiner CM, Canavez F, ''et al.'' |title=Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 22-31 |year= 2001 |pmid= 11169255 |doi=  }}
+* {{cite journal | vauthors = Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL | title = Disulfide bond-mediated dimerization of HLA-G on the cell surface | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 25 | pages = 16180–5 | year = 2003 | pmid = 12454284 | pmc = 138585 | doi = 10.1073/pnas.212643199 }}
-*{{cite journal  | author=Fan QR, Long EO, Wiley DC |title=Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. |journal=Nat. Immunol. |volume=2 |issue= 5 |pages= 452-60 |year= 2001 |pmid= 11323700 |doi= 10.1038/87766 }}
-*{{cite journal  | author=Guerra N, Michel F, Gati A, ''et al.'' |title=Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction. |journal=Blood |volume=100 |issue= 8 |pages= 2874-81 |year= 2002 |pmid= 12351398 |doi= 10.1182/blood-2002-02-0643 }}
-*{{cite journal  | author=Spaggiari GM, Contini P, Dondero A, ''et al.'' |title=Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. |journal=Blood |volume=100 |issue= 12 |pages= 4098-107 |year= 2003 |pmid= 12393468 |doi= 10.1182/blood-2002-04-1284 }}
-*{{cite journal  | author=Boyson JE, Erskine R, Whitman MC, ''et al.'' |title=Disulfide bond-mediated dimerization of HLA-G on the cell surface. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16180-5 |year= 2003 |pmid= 12454284 |doi= 10.1073/pnas.212643199 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
+{{PDB Gallery|geneid=3802}}
+{{Clusters of differentiation}}
 {{NLM content}}
-{{Clusters of differentiation}}
 [[Category:Clusters of differentiation]]
-{{WikiDoc Sources}}
+[[Category:Immunoglobulin superfamily]]
+{{membrane-protein-stub}}
+{{immunology-stub}}

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

KIR2DL1: Difference between revisions

Latest revision as of 06:29, 2 September 2017

Contents

Function

Interactions

See also

References

Further reading

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