CD61

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
PDB rendering based on 1jv2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jv2​, 1l5g​, 1m1x​, 1m8o​, 1txv​, 1ty3​, 1ty5​, 1ty6​, 1ty7​, 1tye​, 1u8c​
Identifiers
Symbols	ITGB3 ; CD61; GP3A; GPIIIa
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55444
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), also known as ITGB3, is a human gene. CD61 is a cluster of differentiation found on thrombocytes.

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

See also

• Glycoprotein IIb/IIIa

Further reading

• Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
• Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936: 340–54. PMID 11460491.
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
• Quinn MJ, Byzova TV, Qin J; et al. (2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian heart journal : official journal of the Italian Federation of Cardiology. 4 (1): 17–22. PMID 12690916.CS1 maint: Multiple names: authors list (link)
• Smith FB, Connor JM, Lee AJ; et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76. PMID 15134555.
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.CS1 maint: Multiple names: authors list (link)
• Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMID 16322781.

External links

• CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)