CD49a: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ck4.
| PDB = {{PDB2|1ck4}}, {{PDB2|1mhp}}, {{PDB2|1pt6}}, {{PDB2|1qc5}}, {{PDB2|1qcy}}, {{PDB2|2b2x}}
| Name = Integrin, alpha 1
| HGNCid = 6134
| Symbol = ITGA1
| AltSymbols =; CD49a; VLA1
| OMIM = 192968
| ECnumber = 
| Homologene = 57137
| MGIid = 96599
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3672
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_852478
    | Hs_RefseqmRNA = NM_181501
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 109700
    | Mm_Ensembl = ENSMUSG00000042284
    | Mm_RefseqmRNA = NM_001033228
    | Mm_RefseqProtein = NP_001028400
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 116080957
    | Mm_GenLoc_end = 116222842
    | Mm_Uniprot = Q05DI0
  }}
}}
'''CD49a''' is an [[integrin]] alpha subunit. It makes up half of the α1β1 integrin duplex.
'''CD49a''' is an [[integrin]] alpha subunit. It makes up half of the α1β1 integrin duplex.


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.<ref name="entrez">{{cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672| accessdate = }}</ref>
| summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for [[collagen]] and [[laminin]]. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.<ref name="entrez">{{cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Virtanen I, Korhonen M, Kariniemi AL, ''et al.'' |title=Integrins in human cells and tumors. |journal=Cell Differ. Dev. |volume=32 |issue= 3 |pages= 215-27 |year= 1991 |pmid= 2099238 |doi=  }}
*{{cite journal  | vauthors=Virtanen I, Korhonen M, Kariniemi AL |title=Integrins in human cells and tumors. |journal=Cell Differ. Dev. |volume=32 |issue= 3 |pages= 215–27 |year= 1991 |pmid= 2099238 |doi=10.1016/0922-3371(90)90034-T |display-authors=etal}}
*{{cite journal  | author=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1-11 |year= 2003 |pmid= 12482545 |doi= }}
*{{cite journal  | vauthors=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1–11 |year= 2003 |pmid= 12482545 |doi=10.1016/S0021-9150(01)00766-3  }}
*{{cite journal  | author=Clover J, Dodds RA, Gowen M |title=Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. |journal=J. Cell. Sci. |volume=103 ( Pt 1) |issue=  |pages= 267-71 |year= 1992 |pmid= 1429908 |doi=  }}
*{{cite journal  | vauthors=Clover J, Dodds RA, Gowen M |title=Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. |journal=J. Cell Sci. |volume=103 |issue=  1|pages= 267–71 |year= 1992 |pmid= 1429908 |doi=  }}
*{{cite journal  | author=Bodary SC, McLean JW |title=The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5938-41 |year= 1990 |pmid= 1690718 |doi=  }}
*{{cite journal  | vauthors=Bodary SC, McLean JW |title=The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5938–41 |year= 1990 |pmid= 1690718 |doi=  }}
*{{cite journal  | author=Sonnenberg A, Linders CJ, Modderman PW, ''et al.'' |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145-55 |year= 1990 |pmid= 1693624 |doi=  }}
*{{cite journal  | vauthors=Sonnenberg A, Linders CJ, Modderman PW |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145–55 |year= 1990 |pmid= 1693624 |doi=10.1083/jcb.110.6.2145  | pmc=2116116 |display-authors=etal}}
*{{cite journal  | author=Belkin VM, Belkin AM, Dol'nikova AE, ''et al.'' |title=[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] |journal=Biokhimiia |volume=56 |issue= 12 |pages= 2198-206 |year= 1992 |pmid= 1807406 |doi=  }}
*{{cite journal  | vauthors=Belkin VM, Belkin AM, Dol'nikova AE |title=[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] |journal=Biokhimiia |volume=56 |issue= 12 |pages= 2198–206 |year= 1992 |pmid= 1807406 |doi=  |display-authors=etal}}
*{{cite journal  | author=Bank I, Roth D, Book M, ''et al.'' |title=Expression and functions of very late antigen 1 in inflammatory joint diseases. |journal=J. Clin. Immunol. |volume=11 |issue= 1 |pages= 29-38 |year= 1991 |pmid= 1827128 |doi=  }}
*{{cite journal  | vauthors=Bank I, Roth D, Book M |title=Expression and functions of very late antigen 1 in inflammatory joint diseases. |journal=J. Clin. Immunol. |volume=11 |issue= 1 |pages= 29–38 |year= 1991 |pmid= 1827128 |doi=10.1007/BF00918792 |display-authors=etal}}
*{{cite journal  | author=Tabibzadeh S |title=Evidence of T-cell activation and potential cytokine action in human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=71 |issue= 3 |pages= 645-9 |year= 1990 |pmid= 2144294 |doi= }}
*{{cite journal  | author=Tabibzadeh S |title=Evidence of T-cell activation and potential cytokine action in human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=71 |issue= 3 |pages= 645–9 |year= 1990 |pmid= 2144294 |doi=10.1210/jcem-71-3-645  }}
*{{cite journal  | author=Tawil NJ, Houde M, Blacher R, ''et al.'' |title=Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. |journal=Biochemistry |volume=29 |issue= 27 |pages= 6540-4 |year= 1990 |pmid= 2169872 |doi=  }}
*{{cite journal  | vauthors=Tawil NJ, Houde M, Blacher R |title=Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. |journal=Biochemistry |volume=29 |issue= 27 |pages= 6540–4 |year= 1990 |pmid= 2169872 |doi=10.1021/bi00479a028  | pmc=2710132 |display-authors=etal}}
*{{cite journal  | author=Belkin VM, Belkin AM, Koteliansky VE |title=Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. |journal=J. Cell Biol. |volume=111 |issue= 5 Pt 1 |pages= 2159-70 |year= 1990 |pmid= 2229189 |doi=  }}
*{{cite journal  | vauthors=Belkin VM, Belkin AM, Koteliansky VE |title=Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. |journal=J. Cell Biol. |volume=111 |issue= 5 Pt 1 |pages= 2159–70 |year= 1990 |pmid= 2229189 |doi=10.1083/jcb.111.5.2159  | pmc=2116325 }}
*{{cite journal  | author=MacDonald TT, Horton MA, Choy MY, Richman PI |title=Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. |journal=J. Clin. Pathol. |volume=43 |issue= 4 |pages= 313-5 |year= 1990 |pmid= 2341567 |doi= }}
*{{cite journal  | vauthors=MacDonald TT, Horton MA, Choy MY, Richman PI |title=Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. |journal=J. Clin. Pathol. |volume=43 |issue= 4 |pages= 313–5 |year= 1990 |pmid= 2341567 |doi=10.1136/jcp.43.4.313  | pmc=502365  }}
*{{cite journal  | author=Takada Y, Strominger JL, Hemler ME |title=The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3239-43 |year= 1987 |pmid= 3033641 |doi=  }}
*{{cite journal  | vauthors=Takada Y, Strominger JL, Hemler ME |title=The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3239–43 |year= 1987 |pmid= 3033641 |doi=10.1073/pnas.84.10.3239  | pmc=304844 }}
*{{cite journal  | author=Hemler ME, Huang C, Schwarz L |title=The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3300-9 |year= 1987 |pmid= 3546305 |doi=  }}
*{{cite journal  | vauthors=Hemler ME, Huang C, Schwarz L |title=The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3300–9 |year= 1987 |pmid= 3546305 |doi=  }}
*{{cite journal  | author=Kono Y, Yang S, Letarte M, Roberts EA |title=Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system. |journal=Exp. Cell Res. |volume=221 |issue= 2 |pages= 478-85 |year= 1996 |pmid= 7493648 |doi= 10.1006/excr.1995.1399 }}
*{{cite journal  | vauthors=Kono Y, Yang S, Letarte M, Roberts EA |title=Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system. |journal=Exp. Cell Res. |volume=221 |issue= 2 |pages= 478–85 |year= 1996 |pmid= 7493648 |doi= 10.1006/excr.1995.1399 }}
*{{cite journal  | author=Eglinton BA, Roberton DM, Cummins AG |title=Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. |journal=Immunol. Cell Biol. |volume=72 |issue= 4 |pages= 306-13 |year= 1995 |pmid= 7806264 |doi=  }}
*{{cite journal  | vauthors=Eglinton BA, Roberton DM, Cummins AG |title=Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. |journal=Immunol. Cell Biol. |volume=72 |issue= 4 |pages= 306–13 |year= 1995 |pmid= 7806264 |doi=10.1038/icb.1994.46 }}
*{{cite journal  | author=Salter DM, Godolphin JL, Gourlay MS |title=Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees. |journal=J. Histochem. Cytochem. |volume=43 |issue= 4 |pages= 447-57 |year= 1995 |pmid= 7897185 |doi=  }}
*{{cite journal  | vauthors=Salter DM, Godolphin JL, Gourlay MS |title=Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees. |journal=J. Histochem. Cytochem. |volume=43 |issue= 4 |pages= 447–57 |year= 1995 |pmid= 7897185 |doi=  10.1177/43.4.7897185}}
*{{cite journal  | author=Pfaff M, Aumailley M, Specks U, ''et al.'' |title=Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI. |journal=Exp. Cell Res. |volume=206 |issue= 1 |pages= 167-76 |year= 1993 |pmid= 8387021 |doi= 10.1006/excr.1993.1134 }}
*{{cite journal  | vauthors=Pfaff M, Aumailley M, Specks U |title=Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI. |journal=Exp. Cell Res. |volume=206 |issue= 1 |pages= 167–76 |year= 1993 |pmid= 8387021 |doi= 10.1006/excr.1993.1134 |display-authors=etal}}
*{{cite journal  | author=Briesewitz R, Epstein MR, Marcantonio EE |title=Expression of native and truncated forms of the human integrin alpha 1 subunit. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2989-96 |year= 1993 |pmid= 8428973 |doi=  }}
*{{cite journal  | vauthors=Briesewitz R, Epstein MR, Marcantonio EE |title=Expression of native and truncated forms of the human integrin alpha 1 subunit. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2989–96 |year= 1993 |pmid= 8428973 |doi=  }}
*{{cite journal  | author=Langholz O, Röckel D, Mauch C, ''et al.'' |title=Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 2 |pages= 1903-15 |year= 1996 |pmid= 8557756 |doi=  }}
*{{cite journal  | vauthors=Langholz O, Röckel D, Mauch C |title=Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 2 |pages= 1903–15 |year= 1996 |pmid= 8557756 |doi=10.1083/jcb.131.6.1903  | pmc=2120685 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
 
{{PDB Gallery|geneid=3672}}


==External links==
==External links==
* {{MeshName|CD49a+antigen}}
* {{MeshName|CD49a+antigen}}
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3672 ITGA1] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
* {{UCSC gene info|ITGA1}}
{{Clusters of differentiation}}
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{{PBB_Controls
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{{Integrins}}
[[Category:Integrins]]


{{immunology-stub}}
{{immunology-stub}}
{{Clusters of differentiation}}
{{WikiDoc Sources}}

Latest revision as of 19:29, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]

References

  1. ↑ "Entrez Gene: ITGA1 integrin, alpha 1".

Further reading

External links



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