CD29

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Identifiers
Symbols	ITGB1 ; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22999
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors.

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

Further reading

• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". Bioessays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
• Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions". Front. Biosci. 7: d219–27. PMID 11779688.
• Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more". Cancer Metastasis Rev. 24 (3): 403–11. doi:10.1007/s10555-005-5132-5. PMID 16258728.

External links

• CD29+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)