Relaxin/insulin-like family peptide receptor 1: Difference between revisions

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{{Infobox_gene}}
 
'''Relaxin/insulin-like family peptide receptor 1''', also known as '''RXFP1''', is a human [[G protein coupled receptor]] that is one of the [[relaxin receptor]]s.<ref name="entrez">{{cite web | title = Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59350| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_RXFP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jm4.
| PDB = {{PDB2|2jm4}}
| Name = Relaxin/insulin-like family peptide receptor 1
| HGNCid = 19718
| Symbol = RXFP1
| AltSymbols =; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177
| OMIM = 606654
| ECnumber = 
| Homologene = 11007
| MGIid = 2682211
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042562 |text = hormone binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007567 |text = parturition}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 59350
    | Hs_Ensembl = ENSG00000171509
    | Hs_RefseqProtein = NP_067647
    | Hs_RefseqmRNA = NM_021634
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 159655440
    | Hs_GenLoc_end = 159792814
    | Hs_Uniprot = Q9HBX9
    | Mm_EntrezGene = 381489
    | Mm_Ensembl = ENSMUSG00000034009
    | Mm_RefseqmRNA = NM_212452
    | Mm_RefseqProtein = NP_997617
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 79730643
    | Mm_GenLoc_end = 79823721
    | Mm_Uniprot = 
  }}
}}
'''Relaxin/insulin-like family peptide receptor 1''', also known as '''RXFP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59350| accessdate = }}</ref>


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==See also==
==See also==
* [[Relaxin receptor]]
* [[Relaxin family peptide hormones]]
* [[Insulin/IGF/Relaxin family]]
* [[Relaxin]]
** [[Relaxin-3]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3022 | title = Relaxin Family Peptide Receptors: RXFP1 | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = }}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Bathgate RA, Ivell R, Sanborn BM, ''et al.'' |title=Receptors for relaxin family peptides. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 61-76 |year= 2005 |pmid= 15956688 |doi= 10.1196/annals.1282.010 }}
*{{cite journal   |vauthors=Bathgate RA, Ivell R, Sanborn BM, etal |title=Receptors for relaxin family peptides |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 61–76 |year= 2005 |pmid= 15956688 |doi= 10.1196/annals.1282.010 }}
*{{cite journal | author=Bathgate RA, Ivell R, Sanborn BM, ''et al.'' |title=International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. |journal=Pharmacol. Rev. |volume=58 |issue= 1 |pages= 7-31 |year= 2006 |pmid= 16507880 |doi= 10.1124/pr.58.1.9 }}
*{{cite journal   |vauthors=Bathgate RA, Ivell R, Sanborn BM, etal |title=International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides |journal=Pharmacol. Rev. |volume=58 |issue= 1 |pages= 7–31 |year= 2006 |pmid= 16507880 |doi= 10.1124/pr.58.1.9 }}
*{{cite journal | author=Hsu SY, Kudo M, Chen T, ''et al.'' |title=The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1257-71 |year= 2001 |pmid= 10935549 |doi=  }}
*{{cite journal   |vauthors=Hsu SY, Kudo M, Chen T, etal |title=The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7 |journal=Mol. Endocrinol. |volume=14 |issue= 8 |pages= 1257–71 |year= 2001 |pmid= 10935549 |doi=10.1210/me.14.8.1257 }}
*{{cite journal  | author=Bartsch O, Bartlick B, Ivell R |title=Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity. |journal=Mol. Hum. Reprod. |volume=7 |issue= 9 |pages= 799-809 |year= 2001 |pmid= 11517286 |doi=  }}
*{{cite journal  | vauthors=Bartsch O, Bartlick B, Ivell R |title=Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity |journal=Mol. Hum. Reprod. |volume=7 |issue= 9 |pages= 799–809 |year= 2001 |pmid= 11517286 |doi=10.1093/molehr/7.9.799 }}
*{{cite journal | author=Hsu SY, Nakabayashi K, Nishi S, ''et al.'' |title=Activation of orphan receptors by the hormone relaxin. |journal=Science |volume=295 |issue= 5555 |pages= 671-4 |year= 2002 |pmid= 11809971 |doi= 10.1126/science.1065654 }}
*{{cite journal   |vauthors=Hsu SY, Nakabayashi K, Nishi S, etal |title=Activation of orphan receptors by the hormone relaxin |journal=Science |volume=295 |issue= 5555 |pages= 671–4 |year= 2002 |pmid= 11809971 |doi= 10.1126/science.1065654 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Sudo S, Kumagai J, Nishi S, ''et al.'' |title=H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7855-62 |year= 2003 |pmid= 12506116 |doi= 10.1074/jbc.M212457200 }}
*{{cite journal   |vauthors=Sudo S, Kumagai J, Nishi S, etal |title=H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7855–62 |year= 2003 |pmid= 12506116 |doi= 10.1074/jbc.M212457200 }}
*{{cite journal | author=Ivell R, Balvers M, Pohnke Y, ''et al.'' |title=Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates. |journal=Reprod. Biol. Endocrinol. |volume=1 |issue=  |pages= 114 |year= 2004 |pmid= 14633277 |doi= 10.1186/1477-7827-1-114 }}
*{{cite journal   |vauthors=Ivell R, Balvers M, Pohnke Y, etal |title=Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates |journal=Reprod. Biol. Endocrinol. |volume=1 |issue=  |pages= 114 |year= 2004 |pmid= 14633277 |doi= 10.1186/1477-7827-1-114 | pmc=293425 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Luna JJ, Riesewijk A, Horcajadas JA, ''et al.'' |title=Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. |journal=Mol. Hum. Reprod. |volume=10 |issue= 2 |pages= 85-90 |year= 2004 |pmid= 14742692 |doi=  }}
*{{cite journal   |vauthors=Luna JJ, Riesewijk A, Horcajadas JA, etal |title=Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle |journal=Mol. Hum. Reprod. |volume=10 |issue= 2 |pages= 85–90 |year= 2004 |pmid= 14742692 |doi=10.1093/molehr/gah019 }}
*{{cite journal | author=Bond CP, Parry LJ, Samuel CS, ''et al.'' |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 7 |pages= 3477-85 |year= 2004 |pmid= 15240635 |doi= 10.1210/jc.2003-030798 }}
*{{cite journal   |vauthors=Bond CP, Parry LJ, Samuel CS, etal |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 7 |pages= 3477–85 |year= 2004 |pmid= 15240635 |doi= 10.1210/jc.2003-030798 }}
*{{cite journal | author=Liu C, Chen J, Kuei C, ''et al.'' |title=Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 231-40 |year= 2005 |pmid= 15465925 |doi= 10.1124/mol.104.006700 }}
*{{cite journal   |vauthors=Liu C, Chen J, Kuei C, etal |title=Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7 |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 231–40 |year= 2005 |pmid= 15465925 |doi= 10.1124/mol.104.006700 }}
*{{cite journal | author=Scott DJ, Layfield S, Riesewijk A, ''et al.'' |title=Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7. |journal=Clin. Exp. Pharmacol. Physiol. |volume=31 |issue= 11 |pages= 828-32 |year= 2005 |pmid= 15566402 |doi= 10.1111/j.1440-1681.2004.04075.x }}
*{{cite journal   |vauthors=Scott DJ, Layfield S, Riesewijk A, etal |title=Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7 |journal=Clin. Exp. Pharmacol. Physiol. |volume=31 |issue= 11 |pages= 828–32 |year= 2005 |pmid= 15566402 |doi= 10.1111/j.1440-1681.2004.04075.x }}
*{{cite journal  | author=Büllesbach EE, Schwabe C |title=The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 14051-6 |year= 2005 |pmid= 15695505 |doi= 10.1074/jbc.M500030200 }}
*{{cite journal  | vauthors=Büllesbach EE, Schwabe C |title=The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7 |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 14051–6 |year= 2005 |pmid= 15695505 |doi= 10.1074/jbc.M500030200 }}
*{{cite journal  | author=Tang M, Mazella J, Zhu HH, Tseng L |title=Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells. |journal=Mol. Hum. Reprod. |volume=11 |issue= 4 |pages= 237-43 |year= 2005 |pmid= 15722441 |doi= 10.1093/molehr/gah149 }}
*{{cite journal  | vauthors=Tang M, Mazella J, Zhu HH, Tseng L |title=Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells |journal=Mol. Hum. Reprod. |volume=11 |issue= 4 |pages= 237–43 |year= 2005 |pmid= 15722441 |doi= 10.1093/molehr/gah149 }}
*{{cite journal  | author=Hopkins EJ, Bathgate RA, Gooley PR |title=The human LGR7 low-density lipoprotein class A module requires calcium for structure. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 27-34 |year= 2005 |pmid= 15956684 |doi= 10.1196/annals.1282.006 }}
*{{cite journal  | vauthors=Hopkins EJ, Bathgate RA, Gooley PR |title=The human LGR7 low-density lipoprotein class A module requires calcium for structure |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 27–34 |year= 2005 |pmid= 15956684 |doi= 10.1196/annals.1282.006 }}
*{{cite journal | author=Bond CP, Parry LJ, Samuel CS, ''et al.'' |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 136-43 |year= 2005 |pmid= 15956698 |doi= 10.1196/annals.1282.020 }}
*{{cite journal   |vauthors=Bond CP, Parry LJ, Samuel CS, etal |title=Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 136–43 |year= 2005 |pmid= 15956698 |doi= 10.1196/annals.1282.020 }}
*{{cite journal  | author=Halls ML, Bathgate RA, Summers RJ |title=Signal switching after stimulation of LGR7 receptors by human relaxin 2. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 288-91 |year= 2005 |pmid= 15956719 |doi= 10.1196/annals.1282.042 }}
*{{cite journal  | vauthors=Halls ML, Bathgate RA, Summers RJ |title=Signal switching after stimulation of LGR7 receptors by human relaxin 2 |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue=  |pages= 288–91 |year= 2005 |pmid= 15956719 |doi= 10.1196/annals.1282.042 }}
*{{cite journal | author=Muda M, He C, Martini PG, ''et al.'' |title=Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity. |journal=Mol. Hum. Reprod. |volume=11 |issue= 8 |pages= 591-600 |year= 2005 |pmid= 16051677 |doi= 10.1093/molehr/gah205 }}
*{{cite journal   |vauthors=Muda M, He C, Martini PG, etal |title=Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity |journal=Mol. Hum. Reprod. |volume=11 |issue= 8 |pages= 591–600 |year= 2005 |pmid= 16051677 |doi= 10.1093/molehr/gah205 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=59350}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Protein and peptide receptor modulators}}
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{{DEFAULTSORT:Relaxin insulin-like family peptide receptor 1}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 15:37, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.[1]


See also

References

  1. "Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.