PDCD1LG2
| Programmed cell death 1 ligand 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PDCD1LG2 ; B7DC; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2; bA574F11.2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10973 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PDCD1LG2 220049 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Programmed cell death 1 ligand 2, also known as PDCD1LG2, is a human gene.[1] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).
References
Further reading
- Latchman Y, Wood CR, Chernova T; et al. (2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat. Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.
- Tseng SY, Otsuji M, Gorski K; et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells". J. Exp. Med. 193 (7): 839–46. PMID 11283156.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Brown JA, Dorfman DM, Ma FR; et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production". J. Immunol. 170 (3): 1257–66. PMID 12538684.
- Youngnak P, Kozono Y, Kozono H; et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1". Biochem. Biophys. Res. Commun. 307 (3): 672–7. PMID 12893276.
- Tsushima F, Iwai H, Otsuki N; et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses". Eur. J. Immunol. 33 (10): 2773–82. doi:10.1002/eji.200324084. PMID 14515261.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Aramaki O, Shirasugi N, Takayama T; et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen". Transplantation. 77 (1): 6–12. doi:10.1097/01.TP.0000108637.65091.4B. PMID 14724428.
- Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
- He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2". Acta Biochim. Biophys. Sin. (Shanghai). 36 (4): 284–9. PMID 15253154.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ohigashi Y, Sho M, Yamada Y; et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer". Clin. Cancer Res. 11 (8): 2947–53. doi:10.1158/1078-0432.CCR-04-1469. PMID 15837746.
- Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion". Eur. J. Immunol. 35 (12): 3561–9. doi:10.1002/eji.200526347. PMID 16278812.
- Pfistershammer K, Klauser C, Pickl WF; et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation". Eur. J. Immunol. 36 (5): 1104–13. doi:10.1002/eji.200535344. PMID 16598819.
- Abelson AK, Johansson CM, Kozyrev SV; et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE". Genes Immun. 8 (1): 69–74. doi:10.1038/sj.gene.6364360. PMID 17136123.
- Mataki N, Kikuchi K, Kawai T; et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases". Am. J. Gastroenterol. 102 (2): 302–12. doi:10.1111/j.1572-0241.2006.00948.x. PMID 17311651.
- Wang SC, Lin CH, Ou TT; et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus". J. Rheumatol. 34 (4): 721–5. PMID 17343323.
External links
- PDCD1LG2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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