KIR2DL1

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
File:PBB Protein KIR2DL1 image.jpg PDB rendering based on 1b6u.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b6u​, 1efx​, 1im9​, 1m4k​, 1nkr​, 2dl2​, 2dli​
Identifiers
Symbols	KIR2DL1 ; 47.11; CD158A; CL-42; KIR-K3; KIR-K64; KIR-K65; KIR-K9; KIR221; NKAT; NKAT1; p58.1; CD158B1; CD158k; CL-43; NKAT6; p58.2; p58; CL-6; CD158B2; CD158b; GL183; KIR-023GB; KIR-K15; KIR-K7c; MGC129943; NKAT2; NKAT2A; NKAT2B; NKR-K7; p58 KIR; CD158H; EB6ActI; EB6ActII; p50.1; KIR2DL3; 183ACTI; CD158J; CL-49; MGC120018; NKAT5; p50.2; NKAT7; 1060P11.7; CD158G; NKAT9
External IDs	Template:OMIM5 HomoloGene: 74998
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, also known as KIR2DL1, is a human gene.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

See also

• Cluster of differentiation

Further reading

• Colonna M, Samaridis J (1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. PMID 7716543.
• Wagtmann N, Biassoni R, Cantoni C; et al. (1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. PMID 7749980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan QR, Mosyak L, Winter CC; et al. (1997). "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors". Nature. 389 (6646): 96–100. doi:10.1038/38028. PMID 9288975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim J, Chwae YJ, Kim MY; et al. (1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875–82. PMID 9378975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valiante NM, Uhrberg M, Shilling HG; et al. (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors". Immunity. 7 (6): 739–51. PMID 9430220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhrberg M, Valiante NM, Shum BP; et al. (1998). "Human diversity in killer cell inhibitory receptor genes". Immunity. 7 (6): 753–63. PMID 9430221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajagopalan S, Long EO (1998). "Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells". J. Immunol. 161 (3): 1299–305. PMID 9686591.
• Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. PMID 9768753.CS1 maint: Multiple names: authors list (link)
• Shilling HG, Lienert-Weidenbach K, Valiante NM; et al. (1998). "Evidence for recombination as a mechanism for KIR diversification". Immunogenetics. 48 (6): 413–6. PMID 9799338.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chwae YJ, Cho SE, Kim SJ, Kim J (1999). "Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual". Immunol. Lett. 68 (2–3): 267–74. PMID 10424431.CS1 maint: Multiple names: authors list (link)
• Fan QR, Wiley DC (1999). "Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor". J. Exp. Med. 190 (1): 113–23. PMID 10429675.
• Richardson J, Reyburn HT, Luque I; et al. (2000). "Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site". Eur. J. Immunol. 30 (5): 1480–5. PMID 10820396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan QR, Long EO, Wiley DC (2000). "A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer". Eur. J. Immunol. 30 (9): 2692–7. doi:10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0. PMID 11009104.CS1 maint: Multiple names: authors list (link)
• Baba E, Erskine R, Boyson JE; et al. (2001). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. PMID 11163076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajalingam R, Gardiner CM, Canavez F; et al. (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens. 57 (1): 22–31. PMID 11169255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan QR, Long EO, Wiley DC (2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700.CS1 maint: Multiple names: authors list (link)
• Guerra N, Michel F, Gati A; et al. (2002). "Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction". Blood. 100 (8): 2874–81. doi:10.1182/blood-2002-02-0643. PMID 12351398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spaggiari GM, Contini P, Dondero A; et al. (2003). "Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction". Blood. 100 (12): 4098–107. doi:10.1182/blood-2002-04-1284. PMID 12393468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boyson JE, Erskine R, Whitman MC; et al. (2003). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMID 12454284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.