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{{Infobox_gene}}
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'''Immunoglobulin lambda-like polypeptide 1''' is a [[protein]] that in humans is encoded by the ''IGLL1'' [[gene]].<ref name="pmid3139558">{{cite journal |vauthors=Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F | title = The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments | journal = Immunogenetics | volume = 28 | issue = 5 | pages = 328–33 |date=Nov 1988 | pmid = 3139558 | pmc =  | doi =10.1007/BF00364231  }}</ref><ref name="pmid2511029">{{cite journal |vauthors=Schiff C, Milili M, Fougereau M | title = Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver | journal = Eur J Immunol | volume = 19 | issue = 10 | pages = 1873–8 |date=Dec 1989 | pmid = 2511029 | pmc = | doi =10.1002/eji.1830191018  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3543| accessdate = }}</ref> IGLL1 has also recently been designated '''CD179B''' ([[cluster of differentiation]] 179B).
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It is associated with [[agammaglobulinemia]]-2.
{{GNF_Protein_box
| image = PBB_Protein_IGLL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h32.
| PDB = {{PDB2|2h32}}, {{PDB2|2h3n}}
| Name = Immunoglobulin lambda-like polypeptide 1
| HGNCid = 5870
| Symbol = IGLL1
| AltSymbols =; 14.1; CD179b; IGL1; IGL5; IGLJ14.1; IGLL; IGO; IGVPB; VPREB2
| OMIM = 146770
| ECnumber = 
| Homologene = 81875
| MGIid = 
| GeneAtlas_image1 = PBB_GE_IGLL1_206660_at_tn.png
| GeneAtlas_image2 = PBB_GE_IGLL1_213502_x_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3543
    | Hs_Ensembl = ENSG00000128322
    | Hs_RefseqProtein = NP_064455
    | Hs_RefseqmRNA = NM_020070
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 22245312
    | Hs_GenLoc_end = 22252495
    | Hs_Uniprot = P15814
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Immunoglobulin lambda-like polypeptide 1''', also known as '''IGLL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3543| accessdate = }}</ref> IGLL1 has also recently been designated '''CD179B''' ([[cluster of differentiation]] 179B).


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3543| accessdate = }}</ref>
| summary_text = The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Evans RJ, Hollis GF |title=Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. |journal=J. Exp. Med. |volume=173 |issue= 2 |pages= 305-11 |year= 1991 |pmid= 1703205 |doi=  }}
*{{cite journal  |vauthors=Evans RJ, Hollis GF |title=Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution |journal=J. Exp. Med. |volume=173 |issue= 2 |pages= 305–11 |year= 1991 |pmid= 1703205 |doi=10.1084/jem.173.2.305  | pmc=2118775 }}
*{{cite journal | author=Bossy D, Milili M, Zucman J, ''et al.'' |title=Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells. |journal=Int. Immunol. |volume=3 |issue= 11 |pages= 1081-90 |year= 1992 |pmid= 1760403 |doi= }}
*{{cite journal   |vauthors=Bossy D, Milili M, Zucman J, etal |title=Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells |journal=Int. Immunol. |volume=3 |issue= 11 |pages= 1081–90 |year= 1992 |pmid= 1760403 |doi=10.1093/intimm/3.11.1081  }}
*{{cite journal | author=Mattei MG, Fumoux F, Roeckel N, ''et al.'' |title=The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus. |journal=Genomics |volume=9 |issue= 3 |pages= 544-6 |year= 1991 |pmid= 1903358 |doi=  }}
*{{cite journal   |vauthors=Mattei MG, Fumoux F, Roeckel N, etal |title=The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus |journal=Genomics |volume=9 |issue= 3 |pages= 544–6 |year= 1991 |pmid= 1903358 |doi=10.1016/0888-7543(91)90422-B }}
*{{cite journal  | author=Tsubata T, Reth M |title=The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. |journal=J. Exp. Med. |volume=172 |issue= 3 |pages= 973-6 |year= 1990 |pmid= 2117639 |doi=  }}
*{{cite journal  |vauthors=Tsubata T, Reth M |title=The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface |journal=J. Exp. Med. |volume=172 |issue= 3 |pages= 973–6 |year= 1990 |pmid= 2117639 |doi=10.1084/jem.172.3.973  | pmc=2188549 }}
*{{cite journal | author=Schiff C, Bensmana M, Guglielmi P, ''et al.'' |title=The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene. |journal=Int. Immunol. |volume=2 |issue= 3 |pages= 201-7 |year= 1991 |pmid= 2128466 |doi=  }}
*{{cite journal   |vauthors=Schiff C, Bensmana M, Guglielmi P, etal |title=The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene |journal=Int. Immunol. |volume=2 |issue= 3 |pages= 201–7 |year= 1991 |pmid= 2128466 |doi=10.1093/intimm/2.3.201 }}
*{{cite journal | author=Hollis GF, Evans RJ, Stafford-Hollis JM, ''et al.'' |title=Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5552-6 |year= 1989 |pmid= 2501791 |doi=  }}
*{{cite journal   |vauthors=Hollis GF, Evans RJ, Stafford-Hollis JM, etal |title=Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5552–6 |year= 1989 |pmid= 2501791 |doi=10.1073/pnas.86.14.5552  | pmc=297661 }}
*{{cite journal | author=Schiff C, Milili M, Fougereau M |title=Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver. |journal=Eur. J. Immunol. |volume=19 |issue= 10 |pages= 1873-8 |year= 1989 |pmid= 2511029 |doi=  }}
*{{cite journal   |vauthors=Chang H, Dmitrovsky E, Hieter PA, etal |title=Identification of three new Ig lambda-like genes in man |journal=J. Exp. Med. |volume=163 |issue= 2 |pages= 425–35 |year= 1986 |pmid= 3003227 |doi=10.1084/jem.163.2.425  | pmc=2188038 }}
*{{cite journal  | author=Chang H, Dmitrovsky E, Hieter PA, ''et al.'' |title=Identification of three new Ig lambda-like genes in man. |journal=J. Exp. Med. |volume=163 |issue= 2 |pages= 425-35 |year= 1986 |pmid= 3003227 |doi=  }}
*{{cite journal  |vauthors=Ohnishi K, Takemori T |title=Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 28347–53 |year= 1994 |pmid= 7961773 |doi=  }}
*{{cite journal | author=Bauer SR, Huebner K, Budarf M, ''et al.'' |title=The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments. |journal=Immunogenetics |volume=28 |issue= 5 |pages= 328-33 |year= 1988 |pmid= 3139558 |doi=  }}
*{{cite journal   |vauthors=Bauer TR, McDermid HE, Budarf ML, etal |title=Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2 |journal=Immunogenetics |volume=38 |issue= 6 |pages= 387–99 |year= 1993 |pmid= 8406611 |doi=10.1007/BF00184519 }}
*{{cite journal | author=Ohnishi K, Takemori T |title=Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 28347-53 |year= 1994 |pmid= 7961773 |doi= }}
*{{cite journal   |vauthors=Sohi MK, Corper AL, Wan T, etal |title=Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4 |journal=Immunology |volume=88 |issue= 4 |pages= 636–41 |year= 1996 |pmid= 8881769 |doi=10.1046/j.1365-2567.1996.d01-692.x  | pmc=1456622  }}
*{{cite journal  | author=Bauer TR, McDermid HE, Budarf ML, ''et al.'' |title=Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2. |journal=Immunogenetics |volume=38 |issue= 6 |pages= 387-99 |year= 1993 |pmid= 8406611 |doi=  }}
*{{cite journal  |vauthors=Donohoe ME, Blomberg BB |title=The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity |journal=J. Immunol. |volume=158 |issue= 4 |pages= 1681–91 |year= 1997 |pmid= 9029104 |doi=  }}
*{{cite journal | author=Sohi MK, Corper AL, Wan T, ''et al.'' |title=Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4. |journal=Immunology |volume=88 |issue= 4 |pages= 636-41 |year= 1996 |pmid= 8881769 |doi=  }}
*{{cite journal   |vauthors=Kawasaki K, Minoshima S, Nakato E, etal |title=One-megabase sequence analysis of the human immunoglobulin lambda gene locus |journal=Genome Res. |volume=7 |issue= 3 |pages= 250–61 |year= 1997 |pmid= 9074928 |doi=10.1101/gr.7.3.250 }}
*{{cite journal | author=Donohoe ME, Blomberg BB |title=The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity. |journal=J. Immunol. |volume=158 |issue= 4 |pages= 1681-91 |year= 1997 |pmid= 9029104 |doi=  }}
*{{cite journal   |vauthors=Corper AL, Sohi MK, Bonagura VR, etal |title=Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction |journal=Nat. Struct. Biol. |volume=4 |issue= 5 |pages= 374–81 |year= 1997 |pmid= 9145108 |doi=10.1038/nsb0597-374 }}
*{{cite journal | author=Kawasaki K, Minoshima S, Nakato E, ''et al.'' |title=One-megabase sequence analysis of the human immunoglobulin lambda gene locus. |journal=Genome Res. |volume=7 |issue= 3 |pages= 250-61 |year= 1997 |pmid= 9074928 |doi=  }}
*{{cite journal   |vauthors=Minegishi Y, Coustan-Smith E, Wang YH, etal |title=Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia |journal=J. Exp. Med. |volume=187 |issue= 1 |pages= 71–7 |year= 1998 |pmid= 9419212 |doi=10.1084/jem.187.1.71  | pmc=2199185 }}
*{{cite journal | author=Corper AL, Sohi MK, Bonagura VR, ''et al.'' |title=Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction. |journal=Nat. Struct. Biol. |volume=4 |issue= 5 |pages= 374-81 |year= 1997 |pmid= 9145108 |doi=  }}
*{{cite journal   |vauthors=Miyazaki T, Kato I, Takeshita S, etal |title=Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines |journal=Int. Immunol. |volume=11 |issue= 8 |pages= 1195–202 |year= 1999 |pmid= 10421777 |doi=10.1093/intimm/11.8.1195 }}
*{{cite journal | author=Minegishi Y, Coustan-Smith E, Wang YH, ''et al.'' |title=Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. |journal=J. Exp. Med. |volume=187 |issue= 1 |pages= 71-7 |year= 1998 |pmid= 9419212 |doi=  }}
*{{cite journal   |vauthors=Donohoe ME, Beck-Engeser GB, Lonberg N, etal |title=Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype |journal=J. Immunol. |volume=164 |issue= 10 |pages= 5269–76 |year= 2000 |pmid= 10799888 |doi=  10.4049/jimmunol.164.10.5269}}
*{{cite journal | author=Miyazaki T, Kato I, Takeshita S, ''et al.'' |title=Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines. |journal=Int. Immunol. |volume=11 |issue= 8 |pages= 1195-202 |year= 1999 |pmid= 10421777 |doi=  }}
*{{cite journal   |vauthors=Nomura K, Kanegane H, Karasuyama H, etal |title=Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway |journal=Blood |volume=96 |issue= 2 |pages= 610–7 |year= 2000 |pmid= 10887125 |doi=  }}
*{{cite journal  | author=Donohoe ME, Beck-Engeser GB, Lonberg N, ''et al.'' |title=Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. |journal=J. Immunol. |volume=164 |issue= 10 |pages= 5269-76 |year= 2000 |pmid= 10799888 |doi=  }}
*{{cite journal  |vauthors=Fang T, Smith BP, Roman CA |title=Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression |journal=J. Immunol. |volume=167 |issue= 7 |pages= 3846–57 |year= 2001 |pmid= 11564802 |doi=  10.4049/jimmunol.167.7.3846}}
*{{cite journal  | author=Nomura K, Kanegane H, Karasuyama H, ''et al.'' |title=Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. |journal=Blood |volume=96 |issue= 2 |pages= 610-7 |year= 2000 |pmid= 10887125 |doi=  }}
*{{cite journal  | author=Fang T, Smith BP, Roman CA |title=Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression. |journal=J. Immunol. |volume=167 |issue= 7 |pages= 3846-57 |year= 2001 |pmid= 11564802 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3543}}


{{membrane-protein-stub}}
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{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Latest revision as of 23:42, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.[1][2][3] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558.
  2. ↑ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029.
  3. ↑ 3.0 3.1 "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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