Glycoprotein IX
| Glycoprotein IX (platelet) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | GP9 ; CD42a; GPIX | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 144 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[1]
Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][1]
See also
References
Further reading
- Kunishima S, Kamiya T, Saito H (2003). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. PMID 12463594.
- Hickey MJ, Deaven LL, Roth GJ (1991). "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3". FEBS Lett. 274 (1–2): 189–92. PMID 2253772.
- Du X, Beutler L, Ruan C; et al. (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524–7. PMID 2436691.
- Andrews RK, Booth WJ, Gorman JJ; et al. (1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–26. PMID 2557900.
- Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773–7. PMID 2771955.
- Roth GJ, Ozols J, Nugent DJ, Williams SA (1988). "Isolation and characterization of human platelet glycoprotein IX". Biochem. Biophys. Res. Commun. 156 (2): 931–9. PMID 3056407.
- Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. PMID 7782333.
- Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ (1994). "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX". Blood. 84 (4): 1124–31. PMID 8049428.
- Hickey MJ, Roth GJ (1993). "Characterization of the gene encoding human platelet glycoprotein IX". J. Biol. Chem. 268 (5): 3438–43. PMID 8429020.
- Wright SD, Michaelides K, Johnson DJ; et al. (1993). "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome". Blood. 81 (9): 2339–47. PMID 8481514.
- Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V.". Blood. 87 (4): 1385–95. PMID 8608228.
- Hollmann C, Haag F, Schlott M; et al. (1996). "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products". Mol. Immunol. 33 (9): 807–17. PMID 8811076.
- Noris P, Simsek S, Stibbe J, von dem Borne AE (1997). "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome". Br. J. Haematol. 97 (2): 312–20. PMID 9163595.
- Hayashi T, Suzuki K, Yahagi A; et al. (1997). "Corrected DNA sequence of the platelet glycoprotein IX gene". Thromb. Haemost. 77 (5): 1034–5. PMID 9184424.
- Bradford HN, Dela Cadena RA, Kunapuli SP; et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood. 90 (4): 1508–15. PMID 9269768.
- Suzuki K, Hayashi T, Yahagi A; et al. (1998). "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome". Br. J. Haematol. 99 (4): 794–800. PMID 9432024.
- Noris P, Arbustini E, Spedini P; et al. (1999). "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV". Br. J. Haematol. 103 (4): 1004–13. PMID 9886312.
- Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. PMID 10429193.
- Kunishima S, Tomiyama Y, Honda S; et al. (2000). "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome". Br. J. Haematol. 107 (3): 539–45. PMID 10583255.
- Rivera CE, Villagra J, Riordan M; et al. (2001). "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome". Br. J. Haematol. 112 (1): 105–8. PMID 11167791.
External links
- GP9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.