CEACAM6: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)''' ('''CEACAM6''') also known as '''CD66c''' ('''C'''luster of '''D'''ifferentiation '''66c'''), is a member of the [[carcinoembryonic antigen]] (CEA) [[gene]] family..<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4680| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
| HGNCid = 1818
| Symbol = CEACAM6
| AltSymbols =; NCA; CD66c; CEAL
| OMIM = 163980
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_CEACAM6_203757_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM6_211657_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4680
    | Hs_Ensembl = ENSG00000086548
    | Hs_RefseqProtein = NP_002474
    | Hs_RefseqmRNA = NM_002483
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 46951337
    | Hs_GenLoc_end = 46967953
    | Hs_Uniprot = P40199
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)''' ('''CEACAM6''') also known as '''CD66c''' ('''C'''luster of '''D'''ifferentiation '''66c'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4680| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Oikawa S, Inuzuka C, Kuroki M, ''et al.'' |title=A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. |journal=J. Biol. Chem. |volume=266 |issue= 13 |pages= 7995-8001 |year= 1991 |pmid= 2022629 |doi=  }}
*{{cite journal  | vauthors=Oikawa S, Inuzuka C, Kuroki M |title=A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. |journal=J. Biol. Chem. |volume=266 |issue= 13 |pages= 7995–8001 |year= 1991 |pmid= 2022629 |doi=  |display-authors=etal}}
*{{cite journal  | author=Haus O, Noworolska A, Laskowski M, ''et al.'' |title=Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia. |journal=Exp. Mol. Pathol. |volume=52 |issue= 2 |pages= 235-42 |year= 1990 |pmid= 2332039 |doi=  }}
*{{cite journal  | vauthors=Haus O, Noworolska A, Laskowski M |title=Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia. |journal=Exp. Mol. Pathol. |volume=52 |issue= 2 |pages= 235–42 |year= 1990 |pmid= 2332039 |doi=10.1016/0014-4800(90)90008-2 |display-authors=etal}}
*{{cite journal  | author=Hefta SA, Paxton RJ, Shively JE |title=Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry. |journal=J. Biol. Chem. |volume=265 |issue= 15 |pages= 8618-26 |year= 1990 |pmid= 2341397 |doi=  }}
*{{cite journal  | vauthors=Hefta SA, Paxton RJ, Shively JE |title=Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry. |journal=J. Biol. Chem. |volume=265 |issue= 15 |pages= 8618–26 |year= 1990 |pmid= 2341397 |doi=  }}
*{{cite journal  | author=Inazawa J, Abe T, Inoue K, ''et al.'' |title=Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2. |journal=Cytogenet. Cell Genet. |volume=52 |issue= 1-2 |pages= 28-31 |year= 1990 |pmid= 2612212 |doi=  }}
*{{cite journal  | vauthors=Inazawa J, Abe T, Inoue K |title=Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2. |journal=Cytogenet. Cell Genet. |volume=52 |issue= 1–2 |pages= 28–31 |year= 1990 |pmid= 2612212 |doi=10.1159/000132833 |display-authors=etal}}
*{{cite journal  | author=Neumaier M, Zimmermann W, Shively L, ''et al.'' |title=Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. |journal=J. Biol. Chem. |volume=263 |issue= 7 |pages= 3202-7 |year= 1988 |pmid= 2830274 |doi=  }}
*{{cite journal  | vauthors=Neumaier M, Zimmermann W, Shively L |title=Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen |journal=J. Biol. Chem. |volume=263 |issue= 7 |pages= 3202–7 |year= 1988 |pmid= 2830274 |doi=  |display-authors=etal}}
*{{cite journal  | author=Kuroki M, Kuroki M, Moore GE, ''et al.'' |title=The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes. |journal=Jpn. J. Cancer Res. |volume=79 |issue= 1 |pages= 82-90 |year= 1988 |pmid= 3128509 |doi= }}
*{{cite journal  | vauthors=Kuroki M, Kuroki M, Moore GE |title=The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes |journal=Jpn. J. Cancer Res. |volume=79 |issue= 1 |pages= 82–90 |year= 1988 |pmid= 3128509 |doi=10.1111/j.1349-7006.1988.tb00014.x  |display-authors=etal}}
*{{cite journal  | author=Barnett T, Goebel SJ, Nothdurft MA, Elting JJ |title=Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. |journal=Genomics |volume=3 |issue= 1 |pages= 59-66 |year= 1989 |pmid= 3220478 |doi=  }}
*{{cite journal  | vauthors=Barnett T, Goebel SJ, Nothdurft MA, Elting JJ |title=Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains |journal=Genomics |volume=3 |issue= 1 |pages= 59–66 |year= 1989 |pmid= 3220478 |doi=10.1016/0888-7543(88)90160-7 }}
*{{cite journal  | author=Tawaragi Y, Oikawa S, Matsuoka Y, ''et al.'' |title=Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence. |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 1 |pages= 89-96 |year= 1988 |pmid= 3337731 |doi=  }}
*{{cite journal  | vauthors=Tawaragi Y, Oikawa S, Matsuoka Y |title=Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 1 |pages= 89–96 |year= 1988 |pmid= 3337731 |doi=10.1016/0006-291X(88)90490-1 |display-authors=etal}}
*{{cite journal  | author=Noworolska A, Harłozińska-Szmyrka A, Richter R |title=Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series. |journal=Cancer Detect. Prev. |volume=9 |issue= 3-4 |pages= 365-71 |year= 1986 |pmid= 3527416 |doi=  }}
*{{cite journal  | vauthors=Noworolska A, Harłozińska-Szmyrka A, Richter R |title=Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series |journal=Cancer Detect. Prev. |volume=9 |issue= 3–4 |pages= 365–71 |year= 1986 |pmid= 3527416 |doi=  }}
*{{cite journal  | author=Oikawa S, Kosaki G, Nakazato H |title=Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA). |journal=Biochem. Biophys. Res. Commun. |volume=146 |issue= 2 |pages= 464-9 |year= 1987 |pmid= 3619891 |doi=  }}
*{{cite journal  | vauthors=Oikawa S, Kosaki G, Nakazato H |title=Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA) |journal=Biochem. Biophys. Res. Commun. |volume=146 |issue= 2 |pages= 464–9 |year= 1987 |pmid= 3619891 |doi=10.1016/0006-291X(87)90552-3 }}
*{{cite journal  | author=Watt SM, Fawcett J, Murdoch SJ, ''et al.'' |title=CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant. |journal=Blood |volume=84 |issue= 1 |pages= 200-10 |year= 1994 |pmid= 8018919 |doi=  }}
*{{cite journal  | vauthors=Watt SM, Fawcett J, Murdoch SJ |title=CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant |journal=Blood |volume=84 |issue= 1 |pages= 200–10 |year= 1994 |pmid= 8018919 |doi=  |display-authors=etal}}
*{{cite journal  | author=Honda Y, Egawa K, Kuroki M, Ono T |title=Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes. |journal=Arch. Dermatol. Res. |volume=289 |issue= 8 |pages= 457-65 |year= 1997 |pmid= 9266023 |doi=  }}
*{{cite journal  | vauthors=Honda Y, Egawa K, Kuroki M, Ono T |title=Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes |journal=Arch. Dermatol. Res. |volume=289 |issue= 8 |pages= 457–65 |year= 1997 |pmid= 9266023 |doi=10.1007/s004030050221 }}
*{{cite journal  | author=Schölzel S, Zimmermann W, Schwarzkopf G, ''et al.'' |title=Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. |journal=Am. J. Pathol. |volume=156 |issue= 2 |pages= 595-605 |year= 2000 |pmid= 10666389 |doi=  }}
*{{cite journal  | vauthors=Schölzel S, Zimmermann W, Schwarzkopf G |title=Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas |journal=Am. J. Pathol. |volume=156 |issue= 2 |pages= 595–605 |year= 2000 |pmid= 10666389 |doi=  10.1016/S0002-9440(10)64764-5| pmc=1850034  |display-authors=etal}}
*{{cite journal  | author=Oikawa S, Sugiyama M, Kuroki M, ''et al.'' |title=Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 564-8 |year= 2001 |pmid= 11095950 |doi= 10.1006/bbrc.2000.3858 }}
*{{cite journal  | vauthors=Oikawa S, Sugiyama M, Kuroki M |title=Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8 |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 564–8 |year= 2001 |pmid= 11095950 |doi= 10.1006/bbrc.2000.3858 |display-authors=etal}}
*{{cite journal  | author=Ilantzis C, DeMarte L, Screaton RA, Stanners CP |title=Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. |journal=Neoplasia |volume=4 |issue= 2 |pages= 151-63 |year= 2002 |pmid= 11896570 |doi= 10.1038/sj/neo/7900201 }}
*{{cite journal  | vauthors=Ilantzis C, DeMarte L, Screaton RA, Stanners CP |title=Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation |journal=Neoplasia |volume=4 |issue= 2 |pages= 151–63 |year= 2002 |pmid= 11896570 |doi=   10.1038/sj.neo.7900201| pmc=1550325 }}
*{{cite journal  | author=Singer BB, Scheffrahn I, Heymann R, ''et al.'' |title=Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5139-46 |year= 2002 |pmid= 11994468 |doi=  }}
*{{cite journal  | vauthors=Singer BB, Scheffrahn I, Heymann R |title=Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5139–46 |year= 2002 |pmid= 11994468 |doi=  10.4049/jimmunol.168.10.5139|display-authors=etal}}
*{{cite journal  | author=Skubitz KM, Campbell KD, Skubitz AP |title=Synthetic peptides from the N-domains of CEACAMs activate neutrophils. |journal=J. Pept. Res. |volume=58 |issue= 6 |pages= 515-26 |year= 2002 |pmid= 12005421 |doi=  }}
*{{cite journal  | vauthors=Skubitz KM, Campbell KD, Skubitz AP |title=Synthetic peptides from the N-domains of CEACAMs activate neutrophils |journal=J. Pept. Res. |volume=58 |issue= 6 |pages= 515–26 |year= 2002 |pmid= 12005421 |doi=10.1034/j.1399-3011.2001.00931.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Taheri M, Saragovi HU, Stanners CP |title=The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14632-9 |year= 2003 |pmid= 12571231 |doi= 10.1074/jbc.M212500200 }}
*{{cite journal  | vauthors=Taheri M, Saragovi HU, Stanners CP |title=The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14632–9 |year= 2003 |pmid= 12571231 |doi= 10.1074/jbc.M212500200 }}
*{{cite journal  | author=Duxbury MS, Ito H, Zinner MJ, ''et al.'' |title=CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. |journal=Oncogene |volume=23 |issue= 2 |pages= 465-73 |year= 2004 |pmid= 14724575 |doi= 10.1038/sj.onc.1207036 }}
*{{cite journal  | vauthors=Duxbury MS, Ito H, Zinner MJ |title=CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells |journal=Oncogene |volume=23 |issue= 2 |pages= 465–73 |year= 2004 |pmid= 14724575 |doi= 10.1038/sj.onc.1207036 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* {{UCSC gene info|CEACAM6}}
* {{MeshName|CEACAM6+protein,+human}}
* {{MeshName|CEACAM6+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Latest revision as of 16:36, 16 February 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c (Cluster of Differentiation 66c), is a member of the carcinoembryonic antigen (CEA) gene family..[1]


See also

References

  1. ↑ "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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