Neuropeptide Y receptor Y1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Neuropeptide Y receptor type 1''' is a [[protein]] that in humans is encoded by the ''NPY1R'' [[gene]].<ref name="pmid8095935">{{cite journal | vauthors = Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J | title = Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6703–7 | date = Mar 1993 | pmid = 8095935 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| accessdate = }}</ref>
'''Neuropeptide Y receptor type 1''' is a [[protein]] that in humans is encoded by the ''NPY1R'' [[gene]].<ref name="pmid8095935">{{cite journal | vauthors = Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J | title = Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor | journal = The Journal of Biological Chemistry | volume = 268 | issue = 9 | pages = 6703–7 | date = March 1993 | pmid = 8095935 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPY1R neuropeptide Y receptor Y1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886| access-date = }}</ref>


== Selective ligands ==
== Selective ligands ==
Line 17: Line 17:
* [[BIBP-3226]] (CAS# 159013-54-4)
* [[BIBP-3226]] (CAS# 159013-54-4)
* PD-160,170 (CAS# 181468-88-2)
* PD-160,170 (CAS# 181468-88-2)
== Available Structures ==
* [http://www.rcsb.org/structure/5ZBH 5ZBH] (Neuropeptide Y1 bound to antagonist BMS-193835)<ref name=":0">{{cite journal | vauthors = Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | title = 1 receptor | language = En | journal = Nature | volume = 556 | issue = 7702 | pages = 520–524 | date = April 2018 | pmid = 29670288 | pmc = 5920736 | doi = 10.1038/s41586-018-0046-x | url = http://www.nature.com/articles/s41586-018-0046-x }}</ref>
* [http://www.rcsb.org/structure/5ZBQ 5ZBQ] (Neuropeptide Y1 bound to antagonist UR-MK299)<ref name=":0" />


== See also ==
== See also ==
Line 26: Line 31:
== Further reading ==
== Further reading ==
{{refbegin|33em}}
{{refbegin|33em}}
* {{cite journal | vauthors = Wan CP, Lau BH | title = Neuropeptide Y receptor subtypes | journal = Life Sciences | volume = 56 | issue = 13 | pages = 1055–64 | date = Feb 1995 | pmid = 9001438 | doi = 10.1016/0024-3205(95)00041-4 }}
* {{cite journal | vauthors = Wan CP, Lau BH | title = Neuropeptide Y receptor subtypes | journal = Life Sciences | volume = 56 | issue = 13 | pages = 1055–64 | date = February 1995 | pmid = 9001438 | doi = 10.1016/0024-3205(95)00041-4 }}
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = Apr 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = April 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
* {{cite journal | vauthors = Bettio A, Beck-Sickinger AG | title = Biophysical methods to study ligand-receptor interactions of neuropeptide Y | journal = Biopolymers | volume = 60 | issue = 6 | pages = 420–37 | year = 2002 | pmid = 12209475 | doi = 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
* {{cite journal | vauthors = Bettio A, Beck-Sickinger AG | title = Biophysical methods to study ligand-receptor interactions of neuropeptide Y | journal = Biopolymers | volume = 60 | issue = 6 | pages = 420–37 | year = 2002 | pmid = 12209475 | doi = 10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W }}
* {{cite journal | vauthors = Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C | title = Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type | journal = The Journal of Biological Chemistry | volume = 267 | issue = 16 | pages = 10935–8 | date = Jun 1992 | pmid = 1317848 | doi =  }}
* {{cite journal | vauthors = Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C | title = Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type | journal = The Journal of Biological Chemistry | volume = 267 | issue = 16 | pages = 10935–8 | date = June 1992 | pmid = 1317848 | doi =  }}
* {{cite journal | vauthors = Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA | title = Cloned human neuropeptide Y receptor couples to two different second messenger systems | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 13 | pages = 5794–8 | date = Jul 1992 | pmid = 1321422 | pmc = 402104 | doi = 10.1073/pnas.89.13.5794 }}
* {{cite journal | vauthors = Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA | title = Cloned human neuropeptide Y receptor couples to two different second messenger systems | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 13 | pages = 5794–8 | date = July 1992 | pmid = 1321422 | pmc = 402104 | doi = 10.1073/pnas.89.13.5794 }}
* {{cite journal | vauthors = Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R | title = Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 39 | pages = 22661–4 | date = Sep 1995 | pmid = 7559383 | doi = 10.1074/jbc.270.39.22661 }}
* {{cite journal | vauthors = Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R | title = Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 39 | pages = 22661–4 | date = September 1995 | pmid = 7559383 | doi = 10.1074/jbc.270.39.22661 }}
* {{cite journal | vauthors = Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL | title = Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6645–55 | date = Feb 2002 | pmid = 11741903 | doi = 10.1074/jbc.M107224200 }}
* {{cite journal | vauthors = Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL | title = Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6645–55 | date = February 2002 | pmid = 11741903 | doi = 10.1074/jbc.M107224200 }}
* {{cite journal | vauthors = Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A | title = Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected] | journal = Peptides | volume = 23 | issue = 1 | pages = 87–96 | date = Jan 2002 | pmid = 11814622 | doi = 10.1016/S0196-9781(01)00583-6 }}
* {{cite journal | vauthors = Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A | title = Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected] | journal = Peptides | volume = 23 | issue = 1 | pages = 87–96 | date = January 2002 | pmid = 11814622 | doi = 10.1016/S0196-9781(01)00583-6 }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = Mar 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = March 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L | title = Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues | journal = Peptides | volume = 23 | issue = 5 | pages = 927–34 | date = May 2002 | pmid = 12084524 | doi = 10.1016/S0196-9781(02)00003-7 }}
* {{cite journal | vauthors = Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L | title = Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues | journal = Peptides | volume = 23 | issue = 5 | pages = 927–34 | date = May 2002 | pmid = 12084524 | doi = 10.1016/S0196-9781(02)00003-7 }}
* {{cite journal | vauthors = Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM | title = Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina | journal = Glia | volume = 39 | issue = 3 | pages = 320–4 | date = Sep 2002 | pmid = 12203398 | doi = 10.1002/glia.10107 }}
* {{cite journal | vauthors = Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM | title = Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina | journal = Glia | volume = 39 | issue = 3 | pages = 320–4 | date = September 2002 | pmid = 12203398 | doi = 10.1002/glia.10107 }}
* {{cite journal | vauthors = Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR | title = The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 306 | issue = 1 | pages = 147–56 | date = Jul 2003 | pmid = 12665544 | doi = 10.1124/jpet.103.051227 }}
* {{cite journal | vauthors = Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR | title = The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 306 | issue = 1 | pages = 147–56 | date = July 2003 | pmid = 12665544 | doi = 10.1124/jpet.103.051227 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Körner M, Waser B, Reubi JC | title = High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia | journal = Clinical Cancer Research | volume = 10 | issue = 24 | pages = 8426–33 | date = Dec 2004 | pmid = 15623622 | doi = 10.1158/1078-0432.CCR-04-0821 }}
* {{cite journal | vauthors = Körner M, Waser B, Reubi JC | title = High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia | journal = Clinical Cancer Research | volume = 10 | issue = 24 | pages = 8426–33 | date = December 2004 | pmid = 15623622 | doi = 10.1158/1078-0432.CCR-04-0821 }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366 | title = Neuropeptide Y Receptors: Y<sub>1</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366 | title = Neuropeptide Y Receptors: Y<sub>1</sub> | access-date = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archive-url = | archive-date = | quote = }}


{{transmembranereceptor-stub}}
{{transmembranereceptor-stub}}
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{{Neuropeptidergics}}
{{Neuropeptidergics}}


[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]

Revision as of 18:01, 24 September 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[1][2]

Selective ligands

Agonists

Antagonists

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures

  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[3]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[3]

See also

References

  1. ↑ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.
  2. ↑ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
  3. ↑ 3.0 3.1 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Neuropeptide_Y_receptor_Y1&oldid=1526236"