GPR77: Difference between revisions

Jump to navigation Jump to search
m (clean up using AWB)
imported>Ser Amantio di Nicolao
 
Line 4: Line 4:
== Function ==
== Function ==


The [[anaphylatoxin]]s C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate [[complement activation]], anaphylatoxins may be involved in [[autoimmunity]] and [[sepsis]]. C5a2 is coexpressed with the [[C5a receptor]], (C5a1, C5aR, C5R1, CD88), on polymorphonuclear [[neutrophil]]s and may modulate C5a1 activity.<ref name="HUGO">{{cite web | title = HUGO| url = http://www.genenames.org/data/hgnc_data.php?hgnc_id=4527| accessdate = }}</ref><ref name="pmid16204243">{{cite journal |vauthors=Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C | title = An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2 | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 39677–80 |date=December 2005 | pmid = 16204243 | doi = 10.1074/jbc.C500287200 }}</ref>
The [[anaphylatoxin]]s C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate [[complement activation]], anaphylatoxins may be involved in [[autoimmunity]] and [[sepsis]]. C5a2 is coexpressed with the [[C5a receptor]], (C5a1, C5aR, C5R1, CD88), on polymorphonuclear [[neutrophil]]s and may modulate C5a1 activity.<ref name="HUGO">{{cite web | title = HUGO| url = https://www.genenames.org/data/hgnc_data.php?hgnc_id=4527| accessdate = }}</ref><ref name="pmid16204243">{{cite journal |vauthors=Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C | title = An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2 | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 39677–80 |date=December 2005 | pmid = 16204243 | doi = 10.1074/jbc.C500287200 }}</ref>


==References==
==References==
Line 30: Line 30:
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}


[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]
 
 
{{transmembranereceptor-stub}}
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.[1][2]

Function

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.[2][3]

References

  1. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
  2. 2.0 2.1 "HUGO".
  3. Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID 16204243.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.