CELSR1: Difference between revisions

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{{Infobox_gene}}
'''Cadherin EGF LAG seven-pass G-type receptor 1''' also known as '''flamingo homolog 2''' or '''cadherin family member 9'''  is a [[protein]] that in humans is encoded by the ''CELSR1'' [[gene]].<ref name="pmid9339365">{{cite journal | vauthors = Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF | title = Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter | journal = Genomics | volume = 45 | issue = 1 | pages = 97–104 |date=Nov 1997 | pmid = 9339365 | pmc =  | doi = 10.1006/geno.1997.4892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = }}</ref>


== Function ==


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The protein encoded by this gene is a member of the flamingo subfamily, part of the [[cadherin]] superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with [[catenin]]s. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two [[laminin]] G-like domains in their [[ectodomain]]. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the [[epidermal growth factor|EGF]]-like domains involved in [[cell adhesion]] and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.<ref name="entrez" />
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
| HGNCid = 1850
| Symbol = CELSR1
| AltSymbols =; ME2; CDHF9; DKFZp434P0729; FMI2; HFMI2
| OMIM = 604523
| ECnumber = 
| Homologene = 7665
| MGIid = 1100883
| GeneAtlas_image1 = PBB_GE_CELSR1_41660_at_tn.png
| GeneAtlas_image2 = PBB_GE_CELSR1_204539_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CELSR1_217262_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0042249 |text = establishment of polarity of embryonic epithelium}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0045176 |text = apical protein localization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9620
    | Hs_Ensembl = ENSG00000075275
    | Hs_RefseqProtein = NP_055061
    | Hs_RefseqmRNA = NM_014246
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 45135395
    | Hs_GenLoc_end = 45311731
    | Hs_Uniprot = Q9NYQ6
    | Mm_EntrezGene = 12614
    | Mm_Ensembl = ENSMUSG00000016028
    | Mm_RefseqmRNA = NM_009886
    | Mm_RefseqProtein = NP_034016
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 85728699
    | Mm_GenLoc_end = 85861536
    | Mm_Uniprot = Q571L9
  }}
}}
'''Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)''', also known as '''CELSR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = }}</ref>
}}


==See also==
==See also==
Line 63: Line 11:
==References==
==References==
{{reflist}}
{{reflist}}
==External links==
* {{UCSC gene info|CELSR1}}
* {{UCSC gene info|ME2}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551-72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
*{{cite journal  | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
*{{cite journal  | author=Hadjantonakis AK, Sheward WJ, Harmar AJ, ''et al.'' |title=Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. |journal=Genomics |volume=45 |issue= 1 |pages= 97-104 |year= 1997 |pmid= 9339365 |doi= 10.1006/geno.1997.4892 }}
*{{cite journal  | vauthors=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=10.1016/S0092-8674(00)80789-8 }}
*{{cite journal  | author=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes. |journal=Cell |volume=97 |issue= 6 |pages= 779-90 |year= 1999 |pmid= 10380929 |doi=  }}
*{{cite journal  | vauthors=Dunham I, Shimizu N, Roe BA |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |display-authors=etal}}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 }}
*{{cite journal  | author=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124-9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 }}
*{{cite journal  | author=Ghosh A |title=Dentritic{{sic|nolink=y}} growth: don't go says flamingo |journal=Neuron |volume=28 |issue= 1 |pages= 3–4 |year= 2000 |pmid= 11086974 |doi=10.1016/S0896-6273(00)00076-3 }}
*{{cite journal  | author=Ghosh A |title=Dentritic growth: don't go says flamingo. |journal=Neuron |volume=28 |issue= 1 |pages= 3-4 |year= 2000 |pmid= 11086974 |doi=  }}
*{{cite journal  | vauthors=Gross J, Grimm O, Ortega G |title=Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family |journal=Psychiatr. Genet. |volume=11 |issue= 4 |pages= 197–200 |year= 2002 |pmid= 11807409 |doi=10.1097/00041444-200112000-00003 |display-authors=etal}}
*{{cite journal  | author=Gross J, Grimm O, Ortega G, ''et al.'' |title=Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family. |journal=Psychiatr. Genet. |volume=11 |issue= 4 |pages= 197-200 |year= 2002 |pmid= 11807409 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Georgieva L, Nikolov I, Poriazova N |title=Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 103–6 |year= 2004 |pmid= 12782967 |doi= 10.1097/01.ypg.0000057486.14812.03 |display-authors=etal}}
*{{cite journal  | author=Georgieva L, Nikolov I, Poriazova N, ''et al.'' |title=Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia. |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 103-6 |year= 2004 |pmid= 12782967 |doi= 10.1097/01.ypg.0000057486.14812.03 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Carroll JS, Liu XS, Brodsky AS |title=Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 |journal=Cell |volume=122 |issue= 1 |pages= 33–43 |year= 2005 |pmid= 16009131 |doi= 10.1016/j.cell.2005.05.008 |display-authors=etal}}
*{{cite journal  | author=Carroll JS, Liu XS, Brodsky AS, ''et al.'' |title=Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. |journal=Cell |volume=122 |issue= 1 |pages= 33-43 |year= 2005 |pmid= 16009131 |doi= 10.1016/j.cell.2005.05.008 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{Chemokine receptors}}
{{G protein-coupled receptors}}
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[[Category:Adhesion GPCRs]]
[[Category:Adhesion GPCRs]]
[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 09:32, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.[1][2]

Function

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[2]

See also

References

  1. ↑ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365.
  2. ↑ 2.0 2.1 "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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