Somatostatin receptor 2: Difference between revisions

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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Somatostatin receptor type 2''' is a [[protein]] that in humans is encoded by the ''SSTR2'' [[gene]].<ref name="pmid8449518">{{cite journal | vauthors = Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI | title = Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms | journal = Genomics | volume = 15 | issue = 2 | pages = 449–52 | date = Feb 1993 | pmid = 8449518 | pmc = | doi = 10.1006/geno.1993.1088 }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Somatostatin receptor 2
| HGNCid = 11331
| Symbol = SSTR2
| AltSymbols =;
| OMIM = 182452
| ECnumber = 
| Homologene = 37427
| MGIid = 98328
| GeneAtlas_image1 = PBB_GE_SSTR2_214597_at_tn.png
| GeneAtlas_image2 = PBB_GE_SSTR2_217455_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004994 |text = somatostatin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6752
    | Hs_Ensembl = ENSG00000180616
    | Hs_RefseqProtein = NP_001041
    | Hs_RefseqmRNA = NM_001050
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 68672755
    | Hs_GenLoc_end = 68679655
    | Hs_Uniprot = P30874
    | Mm_EntrezGene = 20606
    | Mm_Ensembl = ENSMUSG00000047904
    | Mm_RefseqmRNA = XM_990740
    | Mm_RefseqProtein = XP_995834
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 113440347
    | Mm_GenLoc_end = 113441726
    | Mm_Uniprot = P30875
  }}
}}
'''Somatostatin receptor 2''', also known as '''SSTR2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.<ref name="entrez">{{cite web | title = Entrez Gene: SSTR2 somatostatin receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6752| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.<ref name="entrez">{{cite web | title = Entrez Gene: SSTR2 somatostatin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6752| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
Somatostatin receptor 2 has been shown to [[Protein-protein interaction|interact]] with [[SHANK2]].<ref name=pmid10551867>{{cite journal | vauthors = Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ | title = Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 46 | pages = 32997–3001 | date = Nov 1999 | pmid = 10551867 | doi = 10.1074/jbc.274.46.32997 }}</ref>
 
== Therapeutic targeting ==
 
Most [[pituitary adenomas]] express [[SSTR2]], but other [[somatostatin receptors]] are also found.<<ref name="pmid7714115">{{cite journal | vauthors = Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A | title = Somatostatin receptor subtype gene expression in pituitary adenomas | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 80 | issue = 4 | pages = 1386–92 | date = Apr 1995 | pmid = 7714115 | doi = 10.1210/jcem.80.4.7714115 }}</ref> [[Somatostatin]] analogs (i.e. [[Octreotide]], [[Lanreotide]] ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.<ref name="pmid17413185">{{cite journal | vauthors = Zatelli MC, Ambrosio MR, Bondanelli M, Uberti EC | title = Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds | journal = European Journal of Endocrinology / European Federation of Endocrine Societies | volume = 156 Suppl 1 | issue =  | pages = S29-35 | date = Apr 2007 | pmid = 17413185 | doi = 10.1530/eje.1.02352 }}</ref>
 
== See also ==
* [[Somatostatin receptor]]
* [[Somatostatin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S | title = Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 1 | pages = 251–5 | date = Jan 1992 | pmid = 1346068 | pmc = 48214 | doi = 10.1073/pnas.89.1.251 }}
| citations =
* {{cite journal | vauthors = Reubi JC, Waser B, Schaer JC, Markwalder R | title = Somatostatin receptors in human prostate and prostate cancer | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 80 | issue = 9 | pages = 2806–14 | date = Sep 1995 | pmid = 7673428 | doi = 10.1210/jc.80.9.2806 }}
*{{cite journal | author=Yamada Y, Post SR, Wang K, ''et al.'' |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251-5 |year= 1992 |pmid= 1346068 |doi= }}
* {{cite journal | vauthors = Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y | title = Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein | journal = Biochemical and Biophysical Research Communications | volume = 202 | issue = 2 | pages = 1188–95 | date = Jul 1994 | pmid = 7914078 | doi = 10.1006/bbrc.1994.2054 }}
*{{cite journal | author=Reubi JC, Waser B, Schaer JC, Markwalder R |title=Somatostatin receptors in human prostate and prostate cancer. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 9 |pages= 2806-14 |year= 1995 |pmid= 7673428 |doi= }}
* {{cite journal | vauthors = Fujita T, Yamaji Y, Sato M, Murao K, Takahara J | title = Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines | journal = Life Sciences | volume = 55 | issue = 23 | pages = 1797–806 | year = 1994 | pmid = 7968260 | doi = 10.1016/0024-3205(94)90090-6 }}
*{{cite journal | author=Kagimoto S, Yamada Y, Kubota A, ''et al.'' |title=Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 2 |pages= 1188-95 |year= 1994 |pmid= 7914078 |doi= 10.1006/bbrc.1994.2054 }}
* {{cite journal | vauthors = Patel YC, Greenwood M, Kent G, Panetta R, Srikant CB | title = Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation | journal = Biochemical and Biophysical Research Communications | volume = 192 | issue = 1 | pages = 288–94 | date = Apr 1993 | pmid = 8386508 | doi = 10.1006/bbrc.1993.1412 }}
*{{cite journal | author=Fujita T, Yamaji Y, Sato M, ''et al.'' |title=Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. |journal=Life Sci. |volume=55 |issue= 23 |pages= 1797-806 |year= 1994 |pmid= 7968260 |doi= }}
* {{cite journal | vauthors = Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M | title = Identification and characterization of a novel human cortistatin-like peptide | journal = Biochemical and Biophysical Research Communications | volume = 232 | issue = 1 | pages = 157–63 | date = Mar 1997 | pmid = 9125122 | doi = 10.1006/bbrc.1997.6252 }}
*{{cite journal | author=Patel YC, Greenwood M, Kent G, ''et al.'' |title=Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. |journal=Biochem. Biophys. Res. Commun. |volume=192 |issue= 1 |pages= 288-94 |year= 1993 |pmid= 8386508 |doi= 10.1006/bbrc.1993.1412 }}
* {{cite journal | vauthors = Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ | title = Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours | journal = European Journal of Clinical Investigation | volume = 27 | issue = 8 | pages = 639–44 | date = Aug 1997 | pmid = 9279525 | doi = 10.1046/j.1365-2362.1997.1740719.x }}
*{{cite journal | author=Yamada Y, Stoffel M, Espinosa R, ''et al.'' |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449-52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088 }}
* {{cite journal | vauthors = Lopez F, Estève JP, Buscail L, Delesque N, Saint-Laurent N, Théveniau M, Nahmias C, Vaysse N, Susini C | title = The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling | journal = The Journal of Biological Chemistry | volume = 272 | issue = 39 | pages = 24448–54 | date = Sep 1997 | pmid = 9305905 | doi = 10.1074/jbc.272.39.24448 }}
*{{cite journal | author=Fukusumi S, Kitada C, Takekawa S, ''et al.'' |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157-63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252 }}
* {{cite journal | vauthors = Tsutsumi A, Takano H, Ichikawa K, Kobayashi S, Koike T | title = Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells | journal = Cellular Immunology | volume = 181 | issue = 1 | pages = 44–9 | date = Oct 1997 | pmid = 9344495 | doi = 10.1006/cimm.1997.1193 }}
*{{cite journal | author=Jaïs P, Terris B, Ruszniewski P, ''et al.'' |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639-44 |year= 1997 |pmid= 9279525 |doi= }}
* {{cite journal | vauthors = Sharma K, Patel YC, Srikant CB | title = C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 82–90 | date = Jan 1999 | pmid = 9892014 | doi = 10.1210/me.13.1.82 }}
*{{cite journal | author=Lopez F, Estève JP, Buscail L, ''et al.'' |title=The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24448-54 |year= 1997 |pmid= 9305905 |doi= }}
* {{cite journal | vauthors = Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC | title = Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis | journal = Diabetes | volume = 48 | issue = 1 | pages = 77–85 | date = Jan 1999 | pmid = 9892225 | doi = 10.2337/diabetes.48.1.77 }}
*{{cite journal | author=Tsutsumi A, Takano H, Ichikawa K, ''et al.'' |title=Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells. |journal=Cell. Immunol. |volume=181 |issue= 1 |pages= 44-9 |year= 1997 |pmid= 9344495 |doi= 10.1006/cimm.1997.1193 }}
* {{cite journal | vauthors = Zitzer H, Richter D, Kreienkamp HJ | title = Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 26 | pages = 18153–6 | date = Jun 1999 | pmid = 10373412 | doi = 10.1074/jbc.274.26.18153 }}
*{{cite journal | author=Sharma K, Patel YC, Srikant CB |title=C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 82-90 |year= 1999 |pmid= 9892014 |doi= }}
* {{cite journal | vauthors = Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ | title = Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 46 | pages = 32997–3001 | date = Nov 1999 | pmid = 10551867 | doi = 10.1074/jbc.274.46.32997 }}
*{{cite journal | author=Kumar U, Sasi R, Suresh S, ''et al.'' |title=Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. |journal=Diabetes |volume=48 |issue= 1 |pages= 77-85 |year= 1999 |pmid= 9892225 |doi= }}
* {{cite journal | vauthors = Petersenn S, Rasch AC, Presch S, Beil FU, Schulte HM | title = Genomic structure and transcriptional regulation of the human somatostatin receptor type 2 | journal = Molecular and Cellular Endocrinology | volume = 157 | issue = 1-2 | pages = 75–85 | date = Nov 1999 | pmid = 10619399 | doi = 10.1016/S0303-7207(99)00161-6 }}
*{{cite journal | author=Zitzer H, Richter D, Kreienkamp HJ |title=Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18153-6 |year= 1999 |pmid= 10373412 |doi= }}
* {{cite journal | vauthors = Kreienkamp HJ, Zitzer H, Richter D | title = Identification of proteins interacting with the rat somatostatin receptor subtype 2 | journal = Journal of Physiology, Paris | volume = 94 | issue = 3-4 | pages = 193–8 | year = 2001 | pmid = 11087996 | doi = 10.1016/S0928-4257(00)00204-7 }}
*{{cite journal | author=Zitzer H, Hönck HH, Bächner D, ''et al.'' |title=Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32997-3001 |year= 2000 |pmid= 10551867 |doi= }}
* {{cite journal | vauthors = Ho MK, Yung LY, Chan JS, Chan JH, Wong CS, Wong YH | title = Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C | journal = British Journal of Pharmacology | volume = 132 | issue = 7 | pages = 1431–40 | date = Apr 2001 | pmid = 11264236 | pmc = 1572686 | doi = 10.1038/sj.bjp.0703933 }}
*{{cite journal | author=Petersenn S, Rasch AC, Presch S, ''et al.'' |title=Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. |journal=Mol. Cell. Endocrinol. |volume=157 |issue= 1-2 |pages= 75-85 |year= 2000 |pmid= 10619399 |doi= }}
* {{cite journal | vauthors = Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC | title = Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 5 | pages = 2161–9 | date = May 2001 | pmid = 11344221 | doi = 10.1210/jc.86.5.2161 }}
*{{cite journal | author=Kreienkamp HJ, Zitzer H, Richter D |title=Identification of proteins interacting with the rat somatostatin receptor subtype 2. |journal=J. Physiol. Paris |volume=94 |issue= 3-4 |pages= 193-8 |year= 2001 |pmid= 11087996 |doi= }}
* {{cite journal | vauthors = Talme T, Ivanoff J, Hägglund M, Van Neerven RJ, Ivanoff A, Sundqvist KG | title = Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3 | journal = Clinical and Experimental Immunology | volume = 125 | issue = 1 | pages = 71–9 | date = Jul 2001 | pmid = 11472428 | pmc = 1906108 | doi = 10.1046/j.1365-2249.2001.01577.x }}
*{{cite journal | author=Ho MK, Yung LY, Chan JS, ''et al.'' |title=Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C. |journal=Br. J. Pharmacol. |volume=132 |issue= 7 |pages= 1431-40 |year= 2001 |pmid= 11264236 |doi= 10.1038/sj.bjp.0703933 }}
* {{cite journal | vauthors = Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M | title = Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study | journal = Investigative Ophthalmology & Visual Science | volume = 42 | issue = 10 | pages = 2193–201 | date = Sep 2001 | pmid = 11527930 | doi =  }}
*{{cite journal | author=Zatelli MC, Tagliati F, Taylor JE, ''et al.'' |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161-9 |year= 2001 |pmid= 11344221 |doi= }}
*{{cite journal | author=Talme T, Ivanoff J, Hägglund M, ''et al.'' |title=Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 71-9 |year= 2001 |pmid= 11472428 |doi=  }}
*{{cite journal  | author=Klisovic DD, O'Dorisio MS, Katz SE, ''et al.'' |title=Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 10 |pages= 2193-201 |year= 2001 |pmid= 11527930 |doi=  }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1298 IUPHAR Receptor Database - Somatostatin Receptors]
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2433 | title = Somatostatin Receptors: sst<sub>2</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{MeshName|somatostatin+receptor+2}}
* {{MeshName|somatostatin+receptor+2}}


{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{membrane-protein-stub}}
{{GH/IGF-1 axis signaling modulators}}
{{NLM content}}
{{NLM content}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}

Revision as of 00:25, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]

Interactions

Somatostatin receptor 2 has been shown to interact with SHANK2.[3]

Therapeutic targeting

Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[4] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[5]

See also

References

  1. ↑ Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Feb 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
  2. ↑ "Entrez Gene: SSTR2 somatostatin receptor 2".
  3. ↑ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (Nov 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". The Journal of Biological Chemistry. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867.
  4. ↑ Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A (Apr 1995). "Somatostatin receptor subtype gene expression in pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 80 (4): 1386–92. doi:10.1210/jcem.80.4.7714115. PMID 7714115.
  5. ↑ Zatelli MC, Ambrosio MR, Bondanelli M, Uberti EC (Apr 2007). "Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds". European Journal of Endocrinology / European Federation of Endocrine Societies. 156 Suppl 1: S29–35. doi:10.1530/eje.1.02352. PMID 17413185.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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