EDG3

Endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
Identifiers
Symbols	EDG3 ; EDG-3; FLJ37523; LPB3; MGC71696; S1P3; S1PR3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3829
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

EDG3 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

See also

• Lysophospholipid receptor

Further reading

• Hla T, Lee MJ, Ancellin N; et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 16–24. PMID 10818438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.
• Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing". Ann. N. Y. Acad. Sci. 905: 142–58. PMID 10818450.CS1 maint: Multiple names: authors list (link)
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C; et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.CS1 maint: Multiple names: authors list (link)
• An S, Bleu T, Huang W; et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. PMID 9409733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Brocklyn JR, Tu Z, Edsall LC; et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. PMID 9988698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Q, Peyruchaud O, French KJ; et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway". Blood. 93 (9): 2984–90. PMID 10216094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399.
• Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goetzl EJ, Dolezalova H, Kong Y; et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee MJ, Thangada S, Claffey KP; et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. PMID 10555146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. PMID 10617617.CS1 maint: Multiple names: authors list (link)
• Orlati S, Porcelli AM, Hrelia S; et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor". Arch. Biochem. Biophys. 375 (1): 69–77. doi:10.1006/abbi.1999.1589. PMID 10683250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250.CS1 maint: Multiple names: authors list (link)
• Kimura T, Watanabe T, Sato K; et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3". Biochem. J. 348 Pt 1: 71–6. PMID 10794715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR GPCR Database - Lysophospholipid receptors
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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