Somatostatin receptor 4
| Somatostatin receptor 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SSTR4 ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20286 | ||||||||||
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| File:PBB GE SSTR4 214556 at tn.png | |||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Somatostatin receptor 4, also known as SSTR4, is a human gene.[1]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[1]
See also
References
Further reading
- Patel YC (1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology. 20 (3): 157–98. doi:10.1006/frne.1999.0183. PMID 10433861.
- Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.
- Demchyshyn LL, Srikant CB, Sunahara RK; et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Mol. Pharmacol. 43 (6): 894–901. PMID 8100352.
- Yasuda K, Espinosa R, Davis EM; et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–6. doi:10.1006/geno.1993.1410. PMID 8244401.
- Yamada Y, Kagimoto S, Kubota A; et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. PMID 8373420.
- Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1–2): 53–9. PMID 8405411.
- Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
- Rohrer L, Raulf F, Bruns C; et al. (1993). "Cloning and characterization of a fourth human somatostatin receptor". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 4196–200. PMID 8483934.
- Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochem. Biophys. Res. Commun. 193 (2): 648–52. PMID 8512564.
- Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
- de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
- Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.
- Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014.
- Forssell-Aronsson EB, Nilsson O, Bejegård SA; et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". J. Nucl. Med. 41 (4): 636–42. PMID 10768564.
- Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.
- Talme T, Ivanoff J, Hägglund M; et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. PMID 11472428.
- Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.
External links
- IUPHAR Receptor Database - Somatostatin Receptors
- somatostatin+receptor+subtype-4 at the US National Library of Medicine Medical Subject Headings (MeSH)
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