Somatostatin receptor 2

Somatostatin receptor 2
Identifiers
Symbols	SSTR2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37427
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SSTR2 214597 at tn.png
File:PBB GE SSTR2 217455 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Somatostatin receptor 2, also known as SSTR2, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reubi JC, Waser B, Schaer JC, Markwalder R (1995). "Somatostatin receptors in human prostate and prostate cancer". J. Clin. Endocrinol. Metab. 80 (9): 2806–14. PMID 7673428.CS1 maint: Multiple names: authors list (link)
• Kagimoto S, Yamada Y, Kubota A; et al. (1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein". Biochem. Biophys. Res. Commun. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita T, Yamaji Y, Sato M; et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sci. 55 (23): 1797–806. PMID 7968260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patel YC, Greenwood M, Kent G; et al. (1993). "Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation". Biochem. Biophys. Res. Commun. 192 (1): 288–94. doi:10.1006/bbrc.1993.1412. PMID 8386508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lopez F, Estève JP, Buscail L; et al. (1997). "The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling". J. Biol. Chem. 272 (39): 24448–54. PMID 9305905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsutsumi A, Takano H, Ichikawa K; et al. (1997). "Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells". Cell. Immunol. 181 (1): 44–9. doi:10.1006/cimm.1997.1193. PMID 9344495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014.CS1 maint: Multiple names: authors list (link)
• Kumar U, Sasi R, Suresh S; et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. PMID 9892225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zitzer H, Richter D, Kreienkamp HJ (1999). "Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1". J. Biol. Chem. 274 (26): 18153–6. PMID 10373412.CS1 maint: Multiple names: authors list (link)
• Zitzer H, Hönck HH, Bächner D; et al. (2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J. Biol. Chem. 274 (46): 32997–3001. PMID 10551867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petersenn S, Rasch AC, Presch S; et al. (2000). "Genomic structure and transcriptional regulation of the human somatostatin receptor type 2". Mol. Cell. Endocrinol. 157 (1–2): 75–85. PMID 10619399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2". J. Physiol. Paris. 94 (3–4): 193–8. PMID 11087996.CS1 maint: Multiple names: authors list (link)
• Ho MK, Yung LY, Chan JS; et al. (2001). "Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.". Br. J. Pharmacol. 132 (7): 1431–40. doi:10.1038/sj.bjp.0703933. PMID 11264236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Talme T, Ivanoff J, Hägglund M; et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. PMID 11472428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klisovic DD, O'Dorisio MS, Katz SE; et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• somatostatin+receptor+2 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:WikiDoc Sources