Somatostatin receptor 1

Somatostatin receptor 1
Identifiers
Symbols	SSTR1 ; SRIF-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 820
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SSTR1 208482 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Somatostatin receptor 1, also known as SSTR1, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita T, Yamaji Y, Sato M; et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sci. 55 (23): 1797–806. PMID 7968260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1–2): 53–9. PMID 8405411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Romancer M, Cherifi Y, Levasseur S; et al. (1996). "Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae". Life Sci. 58 (13): 1091–8. PMID 8622562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferone D, van Hagen PM, van Koetsveld PM; et al. (1999). "In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells". Endocrinology. 140 (1): 373–80. PMID 9886848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumar U, Sasi R, Suresh S; et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. PMID 9892225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rocheville M, Lange DC, Kumar U; et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. PMID 10713101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwärzler A, Kreienkamp HJ, Richter D (2000). "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast". J. Biol. Chem. 275 (13): 9557–62. PMID 10734105.CS1 maint: Multiple names: authors list (link)
• Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klisovic DD, O'Dorisio MS, Katz SE; et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zatelli MC, Tagliati F, Piccin D; et al. (2002). "Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line". Biochem. Biophys. Res. Commun. 297 (4): 828–34. PMID 12359227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferone D, Pivonello R, Van Hagen PM; et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Notaro A, Bonavolonta' G; et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. PMID 12414882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dizeyi N, Konrad L, Bjartell A; et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urol. Oncol. 7 (3): 91–8. PMID 12474541.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• somatostatin+receptor+type+1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:WikiDoc Sources