Relaxin/insulin-like family peptide receptor 1

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Relaxin/insulin-like family peptide receptor 1
File:PBB Protein RXFP1 image.jpg
PDB rendering based on 2jm4.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols RXFP1 ; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177
External IDs Template:OMIM5 Template:MGI HomoloGene: 11007
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human gene.[1]


See also

References

  1. ↑ "Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1".

Further reading

  • Bathgate RA, Ivell R, Sanborn BM; et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
  • Bathgate RA, Ivell R, Sanborn BM; et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
  • Hsu SY, Kudo M, Chen T; et al. (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. PMID 10935549.
  • Bartsch O, Bartlick B, Ivell R (2001). "Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity". Mol. Hum. Reprod. 7 (9): 799–809. PMID 11517286.
  • Hsu SY, Nakabayashi K, Nishi S; et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Sudo S, Kumagai J, Nishi S; et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
  • Ivell R, Balvers M, Pohnke Y; et al. (2004). "Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates". Reprod. Biol. Endocrinol. 1: 114. doi:10.1186/1477-7827-1-114. PMID 14633277.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Luna JJ, Riesewijk A, Horcajadas JA; et al. (2004). "Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 10 (2): 85–90. PMID 14742692.
  • Bond CP, Parry LJ, Samuel CS; et al. (2004). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (7): 3477–85. doi:10.1210/jc.2003-030798. PMID 15240635.
  • Liu C, Chen J, Kuei C; et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.
  • Scott DJ, Layfield S, Riesewijk A; et al. (2005). "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7". Clin. Exp. Pharmacol. Physiol. 31 (11): 828–32. doi:10.1111/j.1440-1681.2004.04075.x. PMID 15566402.
  • Büllesbach EE, Schwabe C (2005). "The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7". J. Biol. Chem. 280 (14): 14051–6. doi:10.1074/jbc.M500030200. PMID 15695505.
  • Tang M, Mazella J, Zhu HH, Tseng L (2005). "Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells". Mol. Hum. Reprod. 11 (4): 237–43. doi:10.1093/molehr/gah149. PMID 15722441.
  • Hopkins EJ, Bathgate RA, Gooley PR (2005). "The human LGR7 low-density lipoprotein class A module requires calcium for structure". Ann. N. Y. Acad. Sci. 1041: 27–34. doi:10.1196/annals.1282.006. PMID 15956684.
  • Bond CP, Parry LJ, Samuel CS; et al. (2005). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". Ann. N. Y. Acad. Sci. 1041: 136–43. doi:10.1196/annals.1282.020. PMID 15956698.
  • Halls ML, Bathgate RA, Summers RJ (2005). "Signal switching after stimulation of LGR7 receptors by human relaxin 2". Ann. N. Y. Acad. Sci. 1041: 288–91. doi:10.1196/annals.1282.042. PMID 15956719.
  • Muda M, He C, Martini PG; et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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