GPR68: Difference between revisions

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{{Infobox_gene}}
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'''Ovarian cancer G-protein coupled receptor 1''' is a [[protein]] that in humans is encoded by the ''GPR68'' [[gene]].<ref name="pmid8661159">{{cite journal |vauthors=Xu Y, Casey G | title = Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14 | journal = Genomics | volume = 35 | issue = 2 | pages = 397–402 |date=Sep 1996 | pmid = 8661159 | pmc =  | doi = 10.1006/geno.1996.0377 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR68 G protein-coupled receptor 68| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8111| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = G protein-coupled receptor 68
| HGNCid = 4519
| Symbol = GPR68
| AltSymbols =; MGC111379; OGR1
| OMIM = 601404
| ECnumber = 
| Homologene = 2603
| MGIid = 2441763
| GeneAtlas_image1 = PBB_GE_GPR68_211249_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8111
    | Hs_Ensembl = ENSG00000119714
    | Hs_RefseqProtein = NP_003476
    | Hs_RefseqmRNA = NM_003485
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 90768630
    | Hs_GenLoc_end = 90789977
    | Hs_Uniprot = Q15743
    | Mm_EntrezGene = 238377
    | Mm_Ensembl = ENSMUSG00000047415
    | Mm_RefseqmRNA = NM_175493
    | Mm_RefseqProtein = NP_780702
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 101277735
    | Mm_GenLoc_end = 101288931
    | Mm_Uniprot = Q148P7
  }}
}}
'''G protein-coupled receptor 68''', also known as '''GPR68''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR68 G protein-coupled receptor 68| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8111| accessdate = }}</ref>


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==See also==
*[[Proton-sensing G protein-coupled receptors]]


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Xu Y |title=Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. |journal=Biochim. Biophys. Acta |volume=1582 |issue= 1-3 |pages= 81-8 |year= 2002 |pmid= 12069813 |doi=  }}
*{{cite journal  | author=Xu Y |title=Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. |journal=Biochim. Biophys. Acta |volume=1582 |issue= 1–3 |pages= 81–8 |year= 2002 |pmid= 12069813 |doi=  10.1016/S1388-1981(02)00140-3}}
*{{cite journal  | author=An S, Tsai C, Goetzl EJ |title=Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. |journal=FEBS Lett. |volume=375 |issue= 1-2 |pages= 121-4 |year= 1996 |pmid= 7498459 |doi=  }}
*{{cite journal  |vauthors=An S, Tsai C, Goetzl EJ |title=Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. |journal=FEBS Lett. |volume=375 |issue= 1–2 |pages= 121–4 |year= 1996 |pmid= 7498459 |doi=10.1016/0014-5793(95)01196-L  }}
*{{cite journal  | author=Xu Y, Casey G |title=Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. |journal=Genomics |volume=35 |issue= 2 |pages= 397-402 |year= 1996 |pmid= 8661159 |doi= 10.1006/geno.1996.0377 }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Xu Y, Zhu K, Hong G, ''et al.'' |title=Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. |journal=Nat. Cell Biol. |volume=2 |issue= 5 |pages= 261-7 |year= 2000 |pmid= 10806476 |doi= 10.1038/35010529 }}
*{{cite journal   |vauthors=Ludwig MG, Vanek M, Guerini D, etal |title=Proton-sensing G-protein-coupled receptors. |journal=Nature |volume=425 |issue= 6953 |pages= 93–8 |year= 2003 |pmid= 12955148 |doi= 10.1038/nature01905 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bektas M, Barak LS, Jolly PS, etal |title=The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12181–91 |year= 2003 |pmid= 14567679 |doi= 10.1021/bi035051y }}
*{{cite journal | author=Ludwig MG, Vanek M, Guerini D, ''et al.'' |title=Proton-sensing G-protein-coupled receptors. |journal=Nature |volume=425 |issue= 6953 |pages= 93-8 |year= 2003 |pmid= 12955148 |doi= 10.1038/nature01905 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Bektas M, Barak LS, Jolly PS, ''et al.'' |title=The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12181-91 |year= 2003 |pmid= 14567679 |doi= 10.1021/bi035051y }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Radu CG, Nijagal A, McLaughlin J, etal |title=Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 5 |pages= 1632–7 |year= 2005 |pmid= 15665078 |doi= 10.1073/pnas.0409415102 | pmc=545089 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Tomura H, Wang JQ, Komachi M, etal |title=Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34458–64 |year= 2005 |pmid= 16087674 |doi= 10.1074/jbc.M505287200 }}
*{{cite journal | author=Radu CG, Nijagal A, McLaughlin J, ''et al.'' |title=Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 5 |pages= 1632-7 |year= 2005 |pmid= 15665078 |doi= 10.1073/pnas.0409415102 }}
*{{cite journal   |vauthors=Singh LS, Berk M, Oates R, etal |title=Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. |journal=J. Natl. Cancer Inst. |volume=99 |issue= 17 |pages= 1313–27 |year= 2007 |pmid= 17728215 |doi= 10.1093/jnci/djm107 }}
*{{cite journal | author=Tomura H, Wang JQ, Komachi M, ''et al.'' |title=Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34458-64 |year= 2005 |pmid= 16087674 |doi= 10.1074/jbc.M505287200 }}
*{{cite journal | author=Singh LS, Berk M, Oates R, ''et al.'' |title=Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. |journal=J. Natl. Cancer Inst. |volume=99 |issue= 17 |pages= 1313-27 |year= 2007 |pmid= 17728215 |doi= 10.1093/jnci/djm107 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
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[[Category:G protein-coupled receptors]]
{{Transmembranereceptor-stub}}

Latest revision as of 06:24, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.[1][2]


See also

References

  1. ↑ Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
  2. ↑ "Entrez Gene: GPR68 G protein-coupled receptor 68".

Further reading

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