FZD7: Difference between revisions
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'''Frizzled-7''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164 }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | pmc = | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref> | '''Frizzled-7''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164 | bibcode =1998PNAS...9510164T }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | pmc = | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref> | ||
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*{{cite journal |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770 | pmc=21233 |display-authors=etal}} | *{{cite journal |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770 | pmc=21233 |display-authors=etal|bibcode=1997PNAS...94.6770F}} | ||
*{{cite journal |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 }} | *{{cite journal |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }} | *{{cite journal |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }} | ||
*{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}} | *{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}} | *{{cite journal |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}} | *{{cite journal |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}} | ||
*{{cite journal |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal}} | *{{cite journal |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal}} | ||
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{{DEFAULTSORT:Fzd7}} | {{DEFAULTSORT:Fzd7}} | ||
[[Category:G protein coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
{{transmembranereceptor-stub}} | {{transmembranereceptor-stub}} | ||
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Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]
Interactions
FZD7 has been shown to interact with DLG4.[4]
See also
References
- ↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
- ↑ 3.0 3.1 "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
- ↑ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. Netherlands. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.
External links
- "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation. 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene. 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
- Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.
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