5-HT4 receptor

5-hydroxytryptamine (serotonin) receptor 4
Identifiers
Symbols	HTR4 ; 5-HT4; 5-HT4R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20243
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

5-hydroxytryptamine (serotonin) receptor 4, also known as HTR4, is a human gene.

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.

See also

• 5-HT receptor

Further reading

• Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995). "Expression of serotonin receptor mRNAs in blood vessels". FEBS Lett. 370 (3): 215–21. PMID 7656980.CS1 maint: Multiple names: authors list (link)
• Blondel O, Vandecasteele G, Gastineau M; et al. (1997). "Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium". FEBS Lett. 412 (3): 465–74. PMID 9276448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van den Wyngaert I, Gommeren W, Verhasselt P; et al. (1997). "Cloning and expression of a human serotonin 5-HT4 receptor cDNA". J. Neurochem. 69 (5): 1810–9. PMID 9349523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Claeysen S, Faye P, Sebben M; et al. (1997). "Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase". Neuroreport. 8 (15): 3189–96. PMID 9351641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Claeysen S, Faye P, Sebben M; et al. (1997). "Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization". Cytogenet. Cell Genet. 78 (2): 133–4. PMID 9371406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blondel O, Gastineau M, Dahmoune Y; et al. (1998). "Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus". J. Neurochem. 70 (6): 2252–61. PMID 9603189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cichon S, Kesper K, Propping P, Nöthen MM (1998). "Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33)". Mol. Membr. Biol. 15 (2): 75–8. PMID 9724925.CS1 maint: Multiple names: authors list (link)
• Claeysen S, Sebben M, Becamel C; et al. (1999). "Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain". Mol. Pharmacol. 55 (5): 910–20. PMID 10220570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bender E, Pindon A, van Oers I; et al. (2000). "Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant". J. Neurochem. 74 (2): 478–89. PMID 10646498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mialet J, Berque-Bestel I, Eftekhari P; et al. (2000). "Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines". Br. J. Pharmacol. 129 (4): 771–81. doi:10.1038/sj.bjp.0703101. PMID 10683202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bach T, Syversveen T, Kvingedal AM; et al. (2001). "5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle". Naunyn Schmiedebergs Arch. Pharmacol. 363 (2): 146–60. PMID 11218067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Medhurst AD, Lezoualc'h F, Fischmeister R; et al. (2001). "Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR". Brain Res. Mol. Brain Res. 90 (2): 125–34. PMID 11406291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hiroi T, Hayashi-Kobayashi N, Nagumo S; et al. (2002). "Identification and characterization of the human serotonin-4 receptor gene promoter". Biochem. Biophys. Res. Commun. 289 (2): 337–44. doi:10.1006/bbrc.2001.5979. PMID 11716477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vilaró MT, Doménech T, Palacios JM, Mengod G (2002). "Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants". Neuropharmacology. 42 (1): 60–73. PMID 11750916.CS1 maint: Multiple names: authors list (link)
• López-Rodríguez ML, Murcia M, Benhamú B; et al. (2002). "Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin". J. Comput. Aided Mol. Des. 15 (11): 1025–33. PMID 11989623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohtsuki T, Ishiguro H, Detera-Wadleigh SD; et al. (2003). "Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees". Mol. Psychiatry. 7 (9): 954–61. doi:10.1038/sj.mp.4001133. PMID 12399948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Norum JH, Hart K, Levy FO (2003). "Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a)". J. Biol. Chem. 278 (5): 3098–104. doi:10.1074/jbc.M206237200. PMID 12446729.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cartier D, Lihrmann I, Parmentier F; et al. (2003). "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome". J. Clin. Endocrinol. Metab. 88 (1): 248–54. PMID 12519861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manzke T, Guenther U, Ponimaskin EG; et al. (2003). "5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia". Science. 301 (5630): 226–9. doi:10.1126/science.1084674. PMID 12855812.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.