G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[2]
Wntless was shown to be a cargo for the retromer complex.[2] It has been found essential for hair follicle induction.[3]
Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID16678095.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID12761501.
