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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 101''' is a [[protein]] that in humans is encoded by the ''GPR101'' [[gene]].<ref name="pmid11574155">{{cite journal |vauthors=Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 | date = Sep 2001 | pmid = 11574155 | pmc =  | doi = 10.1016/S0378-1119(01)00651-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR101 G protein-coupled receptor 101| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83550| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 101
| HGNCid = 14963
| Symbol = GPR101
| AltSymbols =; GPCR6
| OMIM = 300393
| ECnumber = 
| Homologene = 14273
| MGIid = 2685211
| GeneAtlas_image1 = PBB_GE_GPR101_gnf1h01265_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83550
    | Hs_Ensembl = ENSG00000165370
    | Hs_RefseqProtein = NP_473362
    | Hs_RefseqmRNA = NM_054021
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 135939973
    | Hs_GenLoc_end = 135941499
    | Hs_Uniprot = Q96P66
    | Mm_EntrezGene = 245424
    | Mm_Ensembl = ENSMUSG00000036357
    | Mm_RefseqmRNA = NM_001033360
    | Mm_RefseqProtein = NP_001028532
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 53846588
    | Mm_GenLoc_end = 53850485
    | Mm_Uniprot = Q1WKE2
  }}
}}
'''G protein-coupled receptor 101''', also known as '''GPR101''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR101 G protein-coupled receptor 101| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83550| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{PBB_Summary
 
| section_title =
A [[Gene duplication|duplication event]] in ''GPR101'' is implicated in cases of [[gigantism]] and [[acromegaly]].<ref name="pmid25470569">{{cite journal | vauthors= Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA | title = Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation | journal = N. Engl. J. Med. | volume =  371| issue = | year = 2014 | pmid = 25470569 | doi = 10.1056/NEJMoa1408028 | pages=2363–74 | pmc=4291174}}</ref>
| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR101 G protein-coupled receptor 101| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83550| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
*{{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Lett. | volume = 520 | issue = 1–3 | pages = 97–101 | year = 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 }}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi=  }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[2]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[3]

References

  1. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  2. ↑ 2.0 2.1 "Entrez Gene: GPR101 G protein-coupled receptor 101".
  3. ↑ Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371: 2363–74. doi:10.1056/NEJMoa1408028. PMC 4291174. PMID 25470569.

Further reading

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
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