Rev-ErbA

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nuclear receptor subfamily 1, group D, member 1
Identifiers
SymbolNR1D1
Alt. symbolsear-1, hRev, Rev-ErbAalpha, THRA1
Entrez9572
HUGO7962
OMIM602408
RefSeqNM_021724
UniProtP20393
Other data
LocusChr. 17 q11.2
nuclear receptor subfamily 1, group D, member 2
Identifiers
SymbolNR1D2
Alt. symbolsBD73, RVR, EAR-1r, HZF2, Hs.37288
Entrez9975
HUGO7963
OMIM602304
RefSeqXM_001130839
UniProtQ14995
Other data
LocusChr. 3 p24.1

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).[1][2]

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.[1]

The rev-Erb-α protein is a key regulatory component of the circadian clock.[3][4] In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.[5]

Ligands

References

  1. 1.0 1.1 Lazar MA, Jones KE, Chin WW (1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA Cell Biol. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
  2. Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Mol. Endocrinol. 8 (8): 996–1005. doi:10.1210/me.8.8.996. PMID 7997240.
  3. Yin L, Wang J, Klein PS, Lazar MA (2006). "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock". Science. 311 (5763): 1002–5. doi:10.1126/science.1121613. PMID 16484495.
  4. Wang J, Yin L, Lazar MA (2006). "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1". J. Biol. Chem. 281 (45): 33842–8. doi:10.1074/jbc.M607873200. PMID 16968709.
  5. Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S (2006). "Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis". Arthritis Rheum. 54 (11): 3513–22. doi:10.1002/art.22170. PMID 17075855.

External links



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