CREB3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[1][2]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[2]

See also

Interactions

CREB3 has been shown to interact with Host cell factor C1.[3][4]

References

  1. Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol. 17 (9): 5117–26. PMC 232362. PMID 9271389.
  2. 2.0 2.1 "Entrez Gene: CREB3 cAMP responsive element binding protein 3".
  3. Lu, R; Yang P; Padmakumar S; Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. UNITED STATES. 72 (8): 6291–7. ISSN 0022-538X. PMC 109766. PMID 9658067.
  4. Freiman, R N; Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. UNITED STATES. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754. PMID 9389645.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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