NEUROD2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[3]

References

  1. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
  2. 2.0 2.1 "Entrez Gene: NEUROD2 neurogenic differentiation 2".
  3. Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research. 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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