Swiss-Prot
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Most recent articles on Swiss-Prot | |
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Evidence Based Medicine | |
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Clinical Trials | |
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Ongoing Trials on Swiss-Prot at Clinical Trials.gov Clinical Trials on Swiss-Prot at Google
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Guidelines / Policies / Govt | |
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US National Guidelines Clearinghouse on Swiss-Prot
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Commentary | |
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Definitions | |
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Patient Resources / Community | |
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Patient resources on Swiss-Prot Discussion groups on Swiss-Prot Patient Handouts on Swiss-Prot Directions to Hospitals Treating Swiss-Prot Risk calculators and risk factors for Swiss-Prot
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Healthcare Provider Resources | |
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Causes & Risk Factors for Swiss-Prot | |
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Continuing Medical Education (CME) | |
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International | |
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Experimental / Informatics | |
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Overview
Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.[1] Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.
In 2002, the UniProt consortium was created: it is a collaboration between the Swiss Institute of Bioinformatics, the European Bioinfomatics Institute and the Protein Information Resource (PIR), funded by the National Institutes of Health. Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins.[2] As of 3 April 2007, UniProtKB/Swiss-Prot release 52.2 contains 263,525 entries. As of 3 April 2007, the UniProtKB/TrEMBL release 35.2 contains 4,232,122 entries.
The UniProt consortium produced 3 database components, each optimised for different uses. The UniProt Knowledgebase (UniProtKB (Swiss-Prot + TrEMBL)), the UniProt Non-redundant Reference (UniRef) databases, which combine closely related sequences into a single record to speed similarity searches and the UniProt Archive (UniParc), which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences.
References
- ↑ Bairoch Amos (2000). "Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!". Bioinformatics 16: 48-64. PMID 10812477. — a historical account by Bairoch.
- ↑ Wu, C.H. et al. (January 2006) "The Universal Protein Resource (UniProt): an expanding universe of protein information.". Nucleic Acids Research, 1;34 (Database issue): D187–91.
External links
- Swiss-Prot Protein Database (Swiss Institute of Bioinformatics)
- UniProt (Swiss Institute of Bioinformatics)
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
